ArticleeLife2017
Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in
Open access · goldAbstract read
In one paragraph
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 53 citations in OpenAlex.
- Integrated high-resolution copy number and histomolecular analysis of diffuse hemispheric glioma, H3 G34-mutant reveals universal TP53 abnormalities.Brain pathology (Zurich, Switzerland) · 2026Article
- G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails.Nucleic acids research · 2026Article
- Cancer histone mutations impact protein binding and DNA repair with possible links to genomic instability.Nucleic acids research · 2025Article
- A review of diffuse hemispheric glioma, H3 G34-mutant disease development, DNA repair, microenvironment, and treatments on the horizon.NPJ precision oncology · 2025Review
- Alternative lengthening of telomere-based immortalization renders H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens.Neuro-oncology · 2025Article
- Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype.NAR cancer · 2025Article
- Oncohistone H3 E97K mutation facilitates CENP-A mislocalization and chromosomal instability in budding yeast.Nucleic acids research · 2025Article
- Characterization of oncohistone H2B variants in Schizosaccharomyces pombe reveals a key role of H2B monoubiquitination deficiency in genomic instability by altering gene expression.FEMS yeast research · 2025Article
- Histone H3 mutations and their impact on genome stability maintenance.Biochemical Society transactions · 2024Review
- RebL1 is required for macronuclear structure stability and gametogenesis inMarine life science & technology · 2024Article
- Aberrant DNA repair reveals a vulnerability in histone H3.3-mutant brain tumors.Nucleic acids research · 2024Article
- Emerging roles of cancer-associated histone mutations in genomic instabilities.Frontiers in cell and developmental biology · 2024Review
- Exploring the Molecular Underpinnings of Cancer-Causing Oncohistone Mutants Using Yeast as a Model.Journal of fungi (Basel, Switzerland) · 2023Review
- Post-Translational Modifications in Histones and Their Role in Abiotic Stress Tolerance in Plants.Proteomes · 2023Review
- Review
- Involvement of the H3.3 Histone Variant in the Epigenetic Regulation of Gene Expression in the Nervous System, in Both Physiological and Pathological Conditions.International journal of molecular sciences · 2023Review
- Direct assessment of histone function using histone replacement.Trends in biochemical sciences · 2023Review
- H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models.The Journal of clinical investigation · 2022Article
- A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations.G3 (Bethesda, Md.) · 2022Article
- SETD2: from chromatin modifier to multipronged regulator of the genome and beyond.Cellular and molecular life sciences : CMLS · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Rajesh K YadavDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, United States.
Carolyn M JablonowskiDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, United States.
Alfonso G FernandezDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, United States.
Brandon R LoweDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, United States.
Ryan A HenryDepartment of Cancer Biology, Fox Chase Cancer Center, Philadelphia, United States.
David FinkelsteinDepartment of Bioinformatics, St. Jude Children's Research Hospital, Memphis, United States.
Kevin J BarnumDepartment of Oncological Sciences and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
Alison L PidouxWellcome Trust School for Biological Sciences, University of Edinburgh, Edinburgh, Scotland.
Yin-Ming KuoDepartment of Cancer Biology, Fox Chase Cancer Center, Philadelphia, United States.
Jie HuangDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, United States.
Matthew J O'ConnellDepartment of Oncological Sciences and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
Andrew J AndrewsDepartment of Cancer Biology, Fox Chase Cancer Center, Philadelphia, United States.
Arzu Onar-ThomasDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, United States.
Robin C AllshireWellcome Trust School for Biological Sciences, University of Edinburgh, Edinburgh, Scotland.
Janet F PartridgeDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, United States.ORCID 0000-0003-1102-6305
St. Jude Children's Research Hospital · USFox Chase Cancer Center · USIcahn School of Medicine at Mount Sinai · USWellcome Centre for Cell Biology · GB
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MTRAINING PROGRAM IN CANCER THERAPYT32CA078207 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI James J Manfredi · 1999 to 2026
$11.6MThe Role of Histone Chaperones in Histone Acetylation and Nucleosome DynamicsR01GM102503 · NIGMS · UNIVERSITY OF NORTH CAROLINA WILMINGTON · PI ANDREWS, ANDREW JOSEPH · 2014 to 2023
$3.9MNew determinants of the DNA damage response in the fission yeast S. pombeR01GM087326 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI O'CONNELL, MATTHEW J · 2010 to 2013
$1.3MNCI NIH HHS P30 CA021765NCI NIH HHS T32 CA078207NIGMS NIH HHS R01 GM087326NIGMS NIH HHS R01 GM102503Wellcome Trust 092076/Z/10/ZWellcome Trust 095021/Z/10/ZWellcome Trust 200885/Z/16/Z
Abstract
Recurrent somatic mutations of
Indexed as
DNA ReplicationGenomic InstabilityHomologous RecombinationDNA RepairHistonesMutant ProteinsMutation, MissenseSchizosaccharomycesHistonesMutant ProteinscancerchromatinchromosomesgenesH3K36homologous recombinationS. pombe
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.