SynthesisDer Orthopade2017
The effect of vitamin D and calcium supplementation on falls in older adults : A systematic review and meta-analysis.
Synthesis in Der Orthopade, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2026Pooled it
- Effect of vitamin D, calcium, or combined supplementation on fall prevention: a systematic review and updated network meta-analysis.BMC geriatrics · 2024Pooled it
- Effectiveness of fall prevention interventions in residential aged care and community settings: an umbrella review.BMC geriatrics · 2024Pooled it
- Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.Journal of cachexia, sarcopenia and muscle · 2024Trial
- Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents.Scientific reports · 2021Trial
- Managing consultation duration in primary care: A systematic review with health equity insights.Journal of family medicine and primary care · 2025Review
- Article
- Management of Vertebral Fragility Fracture in Older People: Recommendations from a Spanish Consensus of Experts.Geriatrics (Basel, Switzerland) · 2024Article
- Metabolic bone disorders and the promise of marine osteoactive compounds.Cellular and molecular life sciences : CMLS · 2023Review
- The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults.Redox biology · 2023Article
- Effect of Coenzyme Q10 Supplementation on Sarcopenia, Frailty, and Falls: A Scoping Review.The journal of nutrition, health & aging · 2023Article
- Review
- Article
- Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group.Aging clinical and experimental research · 2022Review
- Review
- Effects of Sleep Duration on Falls in a West Virginia Population-Based Study, BRFSS, 2018.Journal of Appalachian health · 2021Article
- Review
- Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice.Nutrients · 2020Article
- A Pooled Analysis of Fall Incidence From Placebo-Controlled Trials of Denosumab.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA number of studies have hypothesized that vitamin D is a potential factor in the prevention of falls in the elderly; however, the effect of vitamin D is still inconsistent and not quantitative. We conducted this meta-analysis to assess the effect of vitamin D on falls among elderly individuals.
methodsThe PubMed and Cochrane Library databases were searched from the earliest possible year up to December 2016. Two authors working independently reviewed the trials, and odds ratios (ORs) were calculated using a fixed-effect or random-effect model by Review Manager 5.3. We included only double-blind randomized, controlled trials (RCTs) of vitamin D in elderly populations that examined fall results.
resultsA total of 26 articles were included in which 16,540 elderly individuals received vitamin D supplementation, while 16,146 were assigned to control groups. The meta-analysis showed that combined vitamin D plus calcium supplementation has a significant effect on the reduction in the risk of falls (OR for the risk of suffering at least one fall, 0.87; 95% CI, 0.80-0.94). However, no significant association between vitamin D2 or D3 and a reduction in the risk of falls was found (OR, 0.77; 95% CI, 0.58-1.03 for vitamin D2, and OR, 1.08; 95% CI, 0.98-1.20 for vitamin D3).
conclusionsCombined calcium plus vitamin D supplementation is statistically significantly associated with a reduction in fall risks across various populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.