Evidence map›Paper›PMID 28717986›Full record

ArticleIrish journal of medical science2018

Thrombolysis for stroke in Ireland: increasing access and maintaining safety in a challenging environment.

P McElwaine, J McCormack, C Brennan, H Coetzee, P Cotter, R Doyle, A Hickey, F Horgan, C Loughnane, C Macey and 9 more

Abstract read
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In one paragraph

Article in Irish journal of medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Management of acute ischemic stroke, thrombolysis rate, and predictors of clinical outcome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

P McElwaineNational Clinical Programme for Stroke, Health Service Executive, Dublin, Ireland. mcelwaip@tcd.ie.
J McCormackNational Clinical Programme for Stroke, Health Service Executive, Dublin, Ireland.
C BrennanNational Clinical Programme for Stroke, Health Service Executive, Dublin, Ireland.
H CoetzeeIreland East Hospitals Group and University College Dublin, Dublin, Ireland.
P CotterIreland East Hospitals Group and University College Dublin, Dublin, Ireland.
R DoyleIreland East Hospitals Group and University College Dublin, Dublin, Ireland.
A HickeyRoyal College of Surgeons of Ireland, Dublin, Ireland.
F HorganRoyal College of Surgeons of Ireland, Dublin, Ireland.
C LoughnaneIrish Heart Foundation, Dublin, Ireland.
C MaceyIrish Heart Foundation, Dublin, Ireland.
P MarsdenDepartment of Public Health, Health Service Executive, Tullamore, Ireland.
D McCabeTrinity College, University of Dublin, Dublin, Ireland.
R MulcahySouth/South West Hospitals Group, Waterford, Ireland.
I NooneIreland East Hospitals Group and University College Dublin, Dublin, Ireland.
E ShelleyDepartment of Public Health, Health Service Executive, Tullamore, Ireland.
T StapletonTrinity College, University of Dublin, Dublin, Ireland.
D WilliamsRoyal College of Surgeons of Ireland, Dublin, Ireland.
P KellyNational Clinical Programme for Stroke, Health Service Executive, Dublin, Ireland.
J HarbisonNational Clinical Programme for Stroke, Health Service Executive, Dublin, Ireland.ORCID http://orcid.org/0000-0003-3680-5751
University College Dublin · IETrinity College Dublin · IEHealth Service Executive · IERoyal College of Surgeons in Ireland · IEIrish Heart Foundation · IEMercer (Czechia) · CZUniversity Hospital Waterford · IE

Funding

Irish National Lottery N/A
6 · The paper itself

Abstract

backgroundIn the setting of a national audit of acute stroke services, we examined the delivery of thrombolytic therapy for ischaemic stroke and whether current practice was achieving safe outcomes and consistent delivery for patients.

methodData obtained from the recent national stroke audit was compared against previous Irish audit, the most recent SSNAP UK stroke audit and the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) study.

resultsThrombolysis was provided in 27 acute hospitals throughout Ireland during the period assessed with 82% (22/27) providing 24/7 access, the remaining sites using redirect policies. Decision to thrombolyse was made by stroke trained consultants in 63% (17/27) of units, with general physicians and emergency medicine consultants covering the other units. Thrombolysis rate for non-haemorrhagic stroke was 11% (n = 80/742, CI 95% ±2.23) versus a 1% rate in the 2008 audit. Sites receiving patients through a redirect policy had the highest thrombolysis rate, an average of 24%. Nearly 30% of cases were thrombolysed on the weekend. Eighty-three percent of cases were managed in a stroke unit at some time during admission versus 54% of the national total cases. Thirty-seven percent of patients were ≥80 years old. The mortality rate was 11.3% versus the national mortality rate for non-thrombolysed ischaemic strokes of 10% (p > 0.5), and this is comparable to the SITS-MOST 2007 study 3-month mortality rate of 11.3% (p > 0.5).

conclusionStroke thrombolysis is being effectively and safely provided in acute stroke services in Ireland despite regular involvement of non-specialist staff. There is still potential to improve thrombolysis rate.

Indexed as

AgedFemaleFibrinolytic AgentsHumansIrelandMaleStrokeThrombolytic TherapyFibrinolytic AgentsIschaemic strokeNational AuditPatient safetyService organisationStrokeThrombolysis

Identifiers

PMID28717986
OpenAlexW2735302342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.