Trial reportEuropean journal of clinical pharmacology2017
Reduction in targeted potentially inappropriate medication use in elderly inpatients: a pragmatic randomized controlled trial.
Trial report in European journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 9 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Evaluating the role of clinical decision support systems in medication safety for older people: a systematic review.Age and ageing · 2025Pooled it
- Electronic Health Record Interventions to Reduce Risk of Hospital Readmissions: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- A systematic review of outcomes reported in studies to optimise the medication use of patients at hospital discharge.BMC health services research · 2025Pooled it
- Pharmacist interventions in Asian healthcare environments for older people: a systematic review and meta-analysis on hospitalization, mortality, and quality of life.BMC geriatrics · 2024Pooled it
- Medication review in hospitalised patients to reduce morbidity and mortality.The Cochrane database of systematic reviews · 2023Pooled it
- The effects of pharmaceutical interventions on potentially inappropriate medications in older patients: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Detection tools for prediction and identification of adverse drug reactions in older patients: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Reducing Potentially Inappropriate Prescriptions for Older Patients Using Computerized Decision Support Tools: Systematic Review.Journal of medical Internet research · 2019Pooled it
- Interventions to improve the appropriate use of polypharmacy for older people.The Cochrane database of systematic reviews · 2018Pooled it
- Trial
- Potentially inappropriate prescriptions in acutely admitted older patients: a development study to create a clinical decision support tool using a Delphi process.European geriatric medicine · 2026Article
- Clinical decision support systems' effect in reducing medication errors and adverse drug events: an expanded review from Making Healthcare Safer IV.BMJ digital health & AI · 2025Review
- Potentially inappropriate medication in long-term care wards of a veteran hospital in Taiwan: Investigation using a spreadsheet-based rapid assessment tool.Journal of the Chinese Medical Association : JCMA · 2023Article
- How "age-friendly" are deprescribing interventions? A scoping review of deprescribing trials.Health services research · 2023Article
- A pharmacist-led medication review service with a deprescribing focus guided by implementation science.Frontiers in pharmacology · 2023Article
- Use of potentially inappropriate medications and adverse events in older outpatients with acute conditions.Einstein (Sao Paulo, Brazil) · 2022Article
- Effect of Interventions With a Clinical Decision Support System for Hospitalized Older Patients: Systematic Review Mapping Implementation and Design Factors.JMIR medical informatics · 2021Review
- Medication review interventions to reduce hospital readmissions in older people.Journal of the American Geriatrics Society · 2021Review
- Effectiveness of Clinical Pharmacist Service on Drug-Related Problems and Patient Outcomes for Hospitalized Patients with Chronic Kidney Disease: A Randomized Controlled Trial.Journal of clinical medicine · 2021Article
- Reviewing Potentially Inappropriate Medication in Hospitalized Patients Over 65 Using Explicit Criteria: A Systematic Literature Review.Drug, healthcare and patient safety · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe use of potentially inappropriate medications (PIMs) in hospitalized older adults is a complex problem, but the use of computerized alert systems (CAS) has shown some potential. The study's objective is to assess the change in PIM use with a CAS-based pharmacist-physician intervention model compared to usual clinical care.
methodsPragmatic single-site randomized controlled trial was conducted at a university teaching hospital. Hospitalizations identified with selected Beers or STOPP criteria were randomized to usual clinical care or to the CAS-based pharmacist-physician intervention. The primary outcome was PIM drug cessation or dosage decrease. Clinical relevance of the CAS alerts was assessed.
resultsAnalyses included 231 patients who had 128 and 126 hospitalizations in the control and intervention groups, respectively. Patients had a mean age of 81, and 60% were female. In the intervention compared to the control group, drug cessation or dosage decrease were more frequent at 48 h post-alert (45.8 vs 15.9%; absolute difference 30.0%; 95%CI 13.8 to 46.1%) and at discharge from the hospital (48.1 vs 27.3%; absolute difference 20.8%; 95%CI 4.6 to 37.0%). In a post hoc analysis of all alerts, regardless of their clinical relevance, the absolute difference in drug cessation or dosage decrease between the intervention and control groups was 16.2% (95%CI 2.9 to 29.6%) at 48 h and 8.0% (95%CI -4.0 to 20.0%) at discharge from the hospital.
conclusionsIn hospitalized older adults, a CAS-based pharmacist-physician intervention, compared to usual clinical care, resulted in significant higher number of drug cessation and dosage reductions for targeted PIMs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.