ArticleCurrent microbiology2017
Exploring the Genomic Diversity and Cariogenic Differences of Streptococcus mutans Strains Through Pan-Genome and Comparative Genome Analysis.
Article in Current microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Identification and phylogenetic analysis of multidrug resistance, caries-related Streptcoccus mutans in Sulaymaniyah City, Iraqi Kurdistan Region.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Strain-level genomic variation ofPeerJ · 2026Article
- Serotype and distribution of adhesion genes in Streptococcus mutans isolated from people with Parkinson's disease.Odontology · 2025Article
- Synergistic action of specialized metabolites from divergent biosynthesis in the human oral microbiome.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Investigating CRISPR spacer targets and their impact on genomic diversification ofFrontiers in genetics · 2022Article
- Dataset for Genome Sequencing and De Novo Assembly of the Candidate Phyla Radiation in Supragingival Plaque.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- Genomic and phenotypic characterization ofFrontiers in microbiology · 2022Article
- Genotypic and phenotypic characterization ofIranian journal of microbiology · 2021Article
- Proposed virulence-associated genes of Streptococcus suis isolates from the United States serve as predictors of pathogenicity.Porcine health management · 2021Article
- Genetic Analysis of Mutacin B-Ny266, a Lantibiotic Active against Caries Pathogens.Journal of bacteriology · 2020Article
- The Biology ofMicrobiology spectrum · 2019Article
- CovR and VicRKX Regulate Transcription of the Collagen Binding Protein Cnm of Streptococcus mutans.Journal of bacteriology · 2018Article
- Whole genome sequence and phenotypic characterization of a CbmMolecular oral microbiology · 2018Article
- Genome comparison of different Zymomonas mobilis strains provides insights on conservation of the evolution.PloS one · 2018Article
- Evaluation of physical-mechanical properties, antibacterial effect, and cytotoxicity of temporary restorative materials.Journal of applied oral science : revista FOB · 2018Article
- Differences in carbon source usage by dental plaque in children with and without early childhood caries.International journal of oral science · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Pan-genome refers to the sum of genes that can be found in a given bacterial species, including the core-genome and the dispensable genome. In this study, the genomes from 183 Streptococcus mutans (S. mutans) isolates were analyzed from the pan-genome perspective. This analysis revealed that S. mutans has an "open" pan-genome, implying that there are plenty of new genes to be found as more genomes are sequenced. Additionally, S. mutans has a limited core-genome, which is composed of genes related to vital activities within the bacterium, such as metabolism and hereditary information storage or processing, occupying 35.6 and 26.6% of the core genes, respectively. We estimate the theoretical core-genome size to be about 1083 genes, which are fewer than other Streptococcus species. In addition, core genes suffer larger selection pressures in comparison to those that are less widely distributed. Not surprisingly, the distribution of putative virulence genes in S. mutans strains does not correlate with caries status, indicating that other factors are also responsible for cariogenesis. These results contribute to a more understanding of the evolutionary characteristics and dynamic changes within the genome components of the species. This also helps to form a new theoretical foundation for preventing dental caries. Furthermore, this study sets an example for analyzing large genomic datasets of pathogens from the pan-genome perspective.
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Registered trials
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