ArticleThe journal of nutrition, health & aging2017
Prospective Associations of Low Muscle Mass and Function with 10-Year Falls Risk, Incident Fracture and Mortality in Community-Dwelling Older Adults.
Article in The journal of nutrition, health & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prevalence and risk factors of sarcopenia in Asian adults with type 2 diabetes: A systematic review and meta-analysis.Journal of diabetes investigation · 2026Pooled it
- Long-term impact of sarcopenia on functional decline and mortality in community-dwelling older adults: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Association of muscle wasting with mortality risk among adults: A systematic review and meta-analysis of prospective studies.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2019Pooled it
- Association of sarcopenia and fractures in community-dwelling older adults: a systematic review and meta-analysis of cohort studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Effect of a home-based resistance exercise program in elderly participants with osteoporosis: a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Trial
- Trial
- The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study.Clinical interventions in aging · 2019Trial
- Improving Hip Fracture Prediction by Using Sarcopenia-Specific Cut-Offs of T-Scores for Osteosarcopenia: A Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Neck circumference as a predictor of possible sarcopenia in women aged 50-79 years residing in Gwangju, Korea.Nutrition research and practice · 2026Article
- Planetary health diet index and low muscle mass in adults aged 20-60 years: exploratory evaluation of a dairy-upweighted outcome-specific adaptation.Frontiers in nutrition · 2026Article
- Longitudinal association between body mass index and handgrip strength in community-dwelling older adults: a population-based nationwide cohort study.BMC geriatrics · 2025Article
- Multimorbidity, Muscle Strength, and Falls among Older Mexican Americans.Journal of the American Medical Directors Association · 2025Article
- Effect of Protein Supplementation on Orthostatic Hypotension in Older Adult Patients with Heart Failure.Geriatrics (Basel, Switzerland) · 2025Article
- The association between the healthy lifestyle index and MRI-derived body composition measurements in the UK Biobank study.Scientific reports · 2025Article
- The influence of immobility on muscle loss in older people with frailty and fragility fractures.GeroScience · 2024Article
- Among people on osteoporosis medication, loss of appendicular or total body lean mass is an independent risk factor for hip and major osteoporotic fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Resistance exercise training to improve post-operative rehabilitation in knee arthroplasty patients: A narrative review.European journal of sport science · 2024Review
- Sarcopenia definitions and their association with fracture risk in older Swedish women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Relationship between sarcopenia and fatty liver in middle-aged and elderly patients with type 2 diabetes mellitus.Journal of orthopaedic surgery and research · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPurpose: To compare the performance of low muscle mass and function with falls risk, incident fracture and mortality over 10 years.
methods1041 participants (50% women; mean age 63±7.5 years) were prospectively followed for 10 years. Falls risk was measured using the Physiological Profile Assessment, fractures were self-reported and mortality was ascertained from the death registry. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry. Four anthropometric: (ALM/height2, ALM/body mass index, ALM/weight×100, a residuals method of ALM on height and total body fat) and four performance-based measures: (handgrip strength, lower-limb muscle strength, upper and lower-limb muscle quality) were examined. Participants in the lowest 20% of the sex-specific distribution for each anthropometric and performance-based measure were classified has having low muscle mass or function. Regression analyses were used to estimate associations between each anthropometric and performance-based measure at baseline and 10-year falls risk, incident fractures and mortality.
resultsMean falls risk z-score at 10 years was 0.64 (SD 1.12), incident fractures and mortality over 10 years were 16% and 14% respectively. All baseline performance-based measures were significantly associated with higher falls risk score at 10 years. Low handgrip (RR 1.55, 95% CI: 1.09, 2.20) and ALM/body mass index (RR 1.54, 95% CI: 1.14, 2.08) were the only significant predictors of fracture and mortality respectively.
conclusionsLow handgrip strength, a simple and inexpensive test could be considered in clinical settings for identifying future falls and fractures. ALM/ body mass index could be most suitable in estimating 10-year mortality risk, but requires specialised equipment.
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