ArticleJournal of global oncology2016
Pulmonary Nodules in Patients With Nonpulmonary Cancer: Not Always Metastases.
Article in Journal of global oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Stereotactic body radiation therapy and thermal ablation for treatment of patients with pulmonary metastases: a systematic literature review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- The clinical significance of indeterminate pulmonary nodules in patients with primary bone sarcoma: a systematic review.The British journal of radiology · 2024Pooled it
- Semantic CT features and differentiation model: new primary lung cancer versus metastasis after previous malignancy.European radiology · 2026Article
- Synchronous uterine leiomyosarcoma and pulmonary adenocarcinoma in a meerkat (Suricata suricatta): a case report.BMC veterinary research · 2025Article
- New insights into imaging of pulmonary metastases from extra-thoracic neoplasms.La Radiologia medica · 2025Review
- Non-invasive detection of orthotopic human lung tumors by microRNA expression profiling of mouse exhaled breath condensates and exhaled extracellular vesicles.Extracellular vesicles and circulating nucleic acids · 2024Article
- Leiomyosarcoma: Lung Metastasis.Cureus · 2023Article
- The Role of a Multidisciplinary Team in the Diagnosis and Treatment of Bone and Soft Tissue Sarcomas: A Single-Center Experience.Journal of personalized medicine · 2022Article
- Prevalence and clinical characteristics of malignant lung nodules in tuberculosis endemic area in a single tertiary centre.BMC pulmonary medicine · 2022Article
- Is the combination of bilateral pulmonary nodules and mosaic attenuation on chest CT specific for DIPNECH?Orphanet journal of rare diseases · 2021Article
- The diagnosis of pulmonary metastases on chest computed tomography in primary bone sarcoma and musculoskeletal soft tissue sarcoma.The British journal of radiology · 2021Review
- Lung Nodules in Melanoma Patients: Morphologic Criteria to Differentiate Non-Metastatic and Metastatic Lesions.Diagnostics (Basel, Switzerland) · 2021Article
- The value of re-staging chest CT at first local recurrence of extremity and trunk soft tissue sarcoma.European radiology · 2021Article
- The value of chest and skeletal staging in parosteal osteosarcoma: two-centre experience and literature review.Skeletal radiology · 2021Article
- A review of staging chest CT in trunk and extremity soft tissue sarcoma.The British journal of radiology · 2021Article
- Texture analysis of iodine maps and conventional images for k-nearest neighbor classification of benign and metastatic lung nodules.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Development of a Structured Query Language and Natural Language Processing Algorithm to Identify Lung Nodules in a Cancer Centre.Frontiers in medicine · 2021Article
- Lung Metastases Versus Second Primary Lung Cancers in Patients with Primary Urothelial Carcinoma of the Bladder: A National Population-Based Assessment.Bladder cancer (Amsterdam, Netherlands) · 2021Article
- Increased risk of secondary lung cancer in patients with tuberculosis: A nationwide, population-based cohort study.PloS one · 2021Article
- The value of chest and skeletal staging studies in conventional chondrosarcoma.Skeletal radiology · 2021Article
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Authors and funding
9 authors.
Funding
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Abstract
introductionThe differential diagnosis of pulmonary nodules (PNs) includes metastases, lung cancers, infectious diseases, and scar tissue, among others. Because data regarding whether and when to perform a PN biopsy in patients with cancer are scarce, clinicians tend to assume that PNs are metastatic disease based solely on imaging. The current study evaluated the findings of PN biopsies in a population of patients with cancer and sought to determine the variables that correlated with higher odds of metastatic disease. PATIENTS AND
methodsWe conducted a retrospective, single-institution study that included consecutive patients with nonpulmonary solid malignancies who underwent PN biopsy from January 2011 to December 2013. Imaging and clinical variables were analyzed by logistic regression to determine the correlation between such variables and the odds of metastatic disease. Patients with previously known metastatic disease or primary hematologic malignancies were excluded.
resultsTwo hundred twenty-eight patients were included in the study. Metastatic disease was found in 146 patients (64%), 60 patients (26.3%) were diagnosed with a second primary lung tumor, and 22 patients (9.6%) had no cancer on biopsy. On multivariate analysis, the presence of multiple PNs (> 5 mm) and cavitation/necrosis were the only variables associated with higher odds (
conclusionMultiple PNs (> 5 mm) and cavitation were the two characteristics associated with the highest chances of metastatic disease. Our findings demonstrate that PNs should not be assumed to be metastases without performing a biopsy. This assumption may lead to high rates of misdiagnosis. Tissue sampling is fundamental for accurately diagnosing patients with cancer.
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