Evidence map›Paper›PMID 28717643›Full record

ArticleERJ open research2017

Chronic airflow obstruction after successful treatment of multidrug-resistant tuberculosis.

Anthony L Byrne, Ben J Marais, Carole D Mitnick, Frances L Garden, Leonid Lecca, Carmen Contreras, Yaninna Yauri, Fanny Garcia, Guy B Marks

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Multidrug-resistant tuberculosis.Nature reviews. Disease primers · 2024
    Review
  12. Article
  13. Post-TB health and wellbeing.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Pulmonary function and respiratory health after successful treatment of drug-resistant tuberculosis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Anthony L ByrneDepartment of Medicine, Central Clinical School, University of Sydney, Sydney, Australia.
Ben J MaraisDepartment of Medicine, Central Clinical School, University of Sydney, Sydney, Australia.
Carole D MitnickSocios En Salud Sucursal Perú, Partners In Health, Lima, Peru.
Frances L GardenThe Woolcock Institute of Medical Research, Sydney, Australia.
Leonid LeccaSocios En Salud Sucursal Perú, Partners In Health, Lima, Peru.
Carmen ContrerasSocios En Salud Sucursal Perú, Partners In Health, Lima, Peru.
Yaninna YauriMinistry of Health, Red de Salud Lima Ciudad, Lima, Peru.
Fanny GarciaSocios En Salud Sucursal Perú, Partners In Health, Lima, Peru.
Guy B MarksDepartment of Medicine, Central Clinical School, University of Sydney, Sydney, Australia.
EsSALUD · PEUniversity of Sydney · AUHarvard University · USMinistry of Health · PESouth Western Sydney Local Health District · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cross-sectional studies reveal an association between tuberculosis (TB) and chronic airflow obstruction, but cannot adequately address confounding. We hypothesised that treated pulmonary TB is an independent risk factor for chronic airflow obstruction. The Pulmones Post TB cohort study enrolled participants from Lima, Peru, aged 10-70 years with a history of drug-susceptible (DS)- or multidrug-resistant (MDR)-TB who had completed treatment and were clinically cured. Unexposed participants without TB were randomly selected from the same districts. We assessed respiratory symptoms, relevant environmental exposures, and spirometric lung function pre- and post-bronchodilator. In total, 144 participants with DS-TB, 33 with MDR-TB and 161 unexposed participants were fully evaluated. Compared with unexposed participants, MDR-TB patients had lower lung volumes (adjusted mean difference in forced vital capacity -370 mL, 95% CI -644- -97) and post-bronchodilator airflow obstruction (adjusted OR 4.89, 95% CI 1.27-18.78). Participants who had recovered from DS-TB did not have lower lung volumes than unexposed participants, but were more likely to have a reduced forced expiratory volume in 1 s/forced vital capacity ratio <0.70 (adjusted OR 2.47, 95% CI 1.01-6.03). Individuals successfully treated for TB may experience long-lasting sequelae. Interventions facilitating earlier TB treatment and management of chronic respiratory disease should be explored.

Identifiers

PMID28717643
PMCPMC5507160
OpenAlexW2735332495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.