ArticleERJ open research2017
Lung microbiome and host immune tone in subjects with idiopathic pulmonary fibrosis treated with inhaled interferon-γ.
Article in ERJ open research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- The clinical and translational perspectives on the lung microbiome in interstitial lung diseases: a bibliometric review.Journal of thoracic disease · 2026Article
- MDPD reveals specific microbial signatures in human pulmonary diseases.Briefings in bioinformatics · 2026Article
- Air-Pollution-Mediated Microbial Dysbiosis in Health and Disease: Lung-Gut Axis and Beyond.Journal of xenobiotics · 2024Review
- The oncogenic landscape of the idiopathic pulmonary fibrosis: a narrative review.Translational lung cancer research · 2022Review
- Lung Microbiome in Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases.International journal of molecular sciences · 2022Review
- Repeated bronchoscopy in health and obstructive lung disease: is the airway microbiome stable?BMC pulmonary medicine · 2021Article
- Whole lung tissue is the preferred sampling method for amplicon-based characterization of murine lung microbiota.Microbiome · 2021Article
- Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Review
- Microbiota and IPF: hidden and detected relationships.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2021Article
- The evolving role of the lung microbiome in pulmonary fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2020Review
- Updates in using a molecular classifier to identify usual interstitial pneumonia in conventional transbronchial lung biopsy samples.Breathe (Sheffield, England) · 2020Article
- Dysbiosis of lower respiratory tract microbiome are associated with inflammation and microbial function variety.Respiratory research · 2019Article
- Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2019Article
- Prognosticating Outcomes in Interstitial Lung Disease by Mediastinal Lymph Node Assessment. An Observational Cohort Study with Independent Validation.American journal of respiratory and critical care medicine · 2019Observational
- Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer.American journal of respiratory and critical care medicine · 2018Article
- Fibrosis: Lessons from OMICS analyses of the human lung.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Future Research Directions in Pneumonia. NHLBI Working Group Report.American journal of respiratory and critical care medicine · 2018Article
- Screening of a ScFv Antibody With High Affinity for Application in Human IFN-γ Immunoassay.Frontiers in microbiology · 2018Article
- Identification of Halophilic Microbes in Lung Fibrotic Tissue by Oligotyping.Frontiers in microbiology · 2018Article
- The Lung Microbiome in Idiopathic Pulmonary Fibrosis: A Promising Approach for Targeted Therapies.International journal of molecular sciences · 2017Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Therapies targeting inflammation reveal inconsistent results in idiopathic pulmonary fibrosis (IPF). Aerosolised interferon (IFN)-γ has been proposed as a novel therapy. Changes in the host airway microbiome are associated with the inflammatory milieu and may be associated with disease progression. Here, we evaluate whether treatment with aerosolised IFN-γ in IPF impacts either the lower airway microbiome or the host immune phenotype. Patients with IPF who enrolled in an aerosolised IFN-γ trial underwent bronchoscopy at baseline and after 6 months. 16S rRNA sequencing of bronchoalveolar lavage fluid (BALF) was used to evaluate the lung microbiome. Biomarkers were measured by Luminex assay in plasma, BALF and BAL cell supernatant. The compPLS framework was used to evaluate associations between taxa and biomarkers. IFN-γ treatment did not change α or β diversity of the lung microbiome and few taxonomic changes occurred. While none of the biomarkers changed in plasma, there was an increase in IFN-γ and a decrease in Fit-3 ligand, IFN-α2 and interleukin-5 in BAL cell supernatant, and a decrease in tumour necrosis factor-β in BALF. Multiple correlations between microbial taxa common to the oral mucosa and host inflammatory biomarkers were found. These data suggest that the lung microbiome is independently associated with the host immune tone and may have a potential mechanistic role in IPF.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.