Evidence map›Paper›PMID 28717623›Full record

ArticleMuscles, ligaments and tendons journal

Chondrocytes treated with different shock wave devices.

Angela Notarnicola, Florenzo Iannone, Giuseppe Maccagnano, Nuniza Lacarpia, Dorotea Bizzoca, Biagio Moretti

Open access · bronzeAbstract read
In one paragraph

Article in Muscles, ligaments and tendons journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Angela NotarnicolaOrthopaedics Unit, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari, General Hospital, Bari, Italy.
Florenzo IannoneInterdisciplinary Department of Medicine-Rheumatology Unit, University of Bari, General Hospital, Bari, Italy.
Giuseppe MaccagnanoOrthopaedics Unit, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari, General Hospital, Bari, Italy.
Nuniza LacarpiaInterdisciplinary Department of Medicine-Rheumatology Unit, University of Bari, General Hospital, Bari, Italy.
Dorotea BizzocaInterdisciplinary Department of Medicine-Rheumatology Unit, University of Bari, General Hospital, Bari, Italy.
Biagio MorettiOrthopaedics Unit, Department of Basic Medical Science, Neuroscience and Sensory Organs, University of Bari, General Hospital, Bari, Italy.
University of Bari Aldo Moro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundShock wave treatment is used for several orthopedic diseases and there are different devices available. Until now, there have been no experimental studies on the effects of these different generators.

methodsWe carried out an experimental study to compare the effects of three focused generators (electro-magnetic, piezoelectric and electro-hydraulic) as well as a radial generator on healthy and osteoarthritis chondrocytes.

resultsBy the analysis of our results, we may exclude significant differences between the different generators, even though there is a greater action specificity for electro-magnetic and piezoelectric generators.

conclusionsThe smaller size of the focus of the latter two generators guarantees a greater concentration of energy in the target. The biological effect of the increase of IL-10 and reduction of both N-Cadherin and B-Catenin in chondrocytes in healthy subjects and those affected by osteoarthritis confirms the therapeutic potential of ESWT in cartilage diseases, such as osteoarthritis. In clinical practice it is important to introduce the parameter of total energy. This allows us to standardize the treatment and to manage the variability related to the different types of device and size of the focus. LEVEL OF EVIDENCE: IIb.

Indexed as

chondrocytesdevicesshock waves

Identifiers

PMID28717623
PMCPMC5505583
OpenAlexW2735292480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.