ArticleBiomedical optics express2017
Multiphoton microscopy for label-free identification of intramural metastasis in human esophageal squamous cell carcinoma.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Towards next-generation diagnostic pathology: AI-empowered label-free multiphoton microscopy.Light, science & applications · 2024Review
- Highly-selective optical filter for NADH fluorescence detection in multiphoton microscopy.Biomedical optics express · 2024Article
- Toward next-generation endoscopes integrating biomimetic video systems, nonlinear optical microscopy, and deep learning.Biophysics reviews · 2023Review
- Visualization of lymphatic vascular invasion in breast cancer by multiphoton microscopy.Lasers in medical science · 2021Article
- Optical biopsy of laryngeal lesions using femtosecond multiphoton microscopy.Biomedical optics express · 2021Article
- Label-free characterization of collagen fibers in cancerous esophagus tissues using ratiometric nonlinear optical microscopy.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Multimodal imaging platform for optical virtual skin biopsy enabled by a fiber-based two-color ultrafast laser source.Biomedical optics express · 2019Article
- Article
- Label-free classification of hepatocellular-carcinoma grading using second harmonic generation microscopy.Biomedical optics express · 2018Article
- Spatial and temporal identification of cerebral infarctions based on multiphoton microscopic imaging.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For complete removal of cancerous tissue in esophageal squamous cell carcinoma (ESCC), intramural metastasis (IM) should be identified preoperatively or intraoperatively. Here, multiphoton microscopy (MPM) was introduced for label-free identification of IM in the esophageal wall, by a combination of two-photon excited fluorescence (TPEF), second harmonic generation (SHG) imaging, and spectral analysis. Three-dimensional (3D) imaging of the IM region was also performed. Quantitative parameters, including 3D fiber orientation, were measured by 3D-weighted orientation vector summation. Overall, MPM showed the potential to identify IM. With the development of the advanced MPM endoscope, clinical identification of IM by MPM will be possible.
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