ArticleBiomedical optics express2017
Visible spectrum extended-focus optical coherence microscopy for label-free sub-cellular tomography.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Ultrabroadband OCT for simultaneous visible and near-infrared light imaging of the mouse retina.Biomedical optics express · 2026Article
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Dual-parameter tomographic imaging of attenuation and backscattering coefficients for quantitative evaluation of immune cell-mediated cytotoxicity in tumor spheroids.Theranostics · 2025Article
- Computational approach for correcting defocus and suppressing speckle noise in line-field optical coherence tomography images.Biomedical optics express · 2024Article
- Probe fusion all-optic OCT-PAM dual-mode imaging system for biomedical imaging.Photoacoustics · 2024Article
- Correcting spatial-spectral crosstalk and chromatic aberrations in broadband line-scan spectral-domain OCT images.Biomedical optics express · 2023Article
- Corneal imaging with blue-light optical coherence microscopy.Biomedical optics express · 2022Article
- Flexible method for generating needle-shaped beams and its application in optical coherence tomography.Optica · 2022Article
- Intravital 3D visualization and segmentation of murine neural networks at micron resolution.Scientific reports · 2022Article
- Ultrahigh resolution spectral-domain optical coherence tomography using the 1000-1600 nm spectral band.Biomedical optics express · 2022Article
- Spectroscopic thermo-elastic optical coherence tomography for tissue characterization.Biomedical optics express · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- Extended focal depth Fourier domain optical coherence microscopy with a Bessel-beam - LPBiomedical optics express · 2021Article
- Reconstruction of visible light optical coherence tomography images retrieved from discontinuous spectral data using a conditional generative adversarial network.Biomedical optics express · 2021Article
- Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast.Biomedical optics express · 2021Article
- Three-dimensional virtual histology in unprocessed resected tissues with photoacoustic remote sensing (PARS) microscopy and optical coherence tomography (OCT).Scientific reports · 2021Article
- Soliton microcomb based spectral domain optical coherence tomography.Nature communications · 2021Article
- The Progress of Label-Free Optical Imaging in Alzheimer's Disease Screening and Diagnosis.Frontiers in aging neuroscience · 2021Review
- Full-field spectral-domain optical interferometry for snapshot three-dimensional microscopy.Biomedical optics express · 2020Article
- Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning.Cancers · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a novel extended-focus optical coherence microscope (OCM) attaining 0.7 μm axial and 0.4 μm lateral resolution maintained over a depth of 40 μm, while preserving the advantages of Fourier domain OCM. Our system uses an ultra-broad spectrum from a supercontinuum laser source. As the spectrum spans from near-infrared to visible wavelengths (240 nm in bandwidth), we call the system visOCM. The combination of such a broad spectrum with a high-NA objective creates an almost isotropic 3D submicron resolution. We analyze the imaging performance of visOCM on microbead samples and demonstrate its image quality on cell cultures and ex-vivo brain tissue of both healthy and alzheimeric mice. In addition to neuronal cell bodies, fibers and plaques, visOCM imaging of brain tissue reveals fine vascular structures and sub-cellular features through its high spatial resolution. Sub-cellular structures were also observed in live cells and were further revealed through a protocol traditionally used for OCT angiography.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.