Evidence map›Paper›PMID 28717568›Full record

ArticleBiomedical optics express2017

Robust total retina thickness segmentation in optical coherence tomography images using convolutional neural networks.

Freerk G Venhuizen, Bram van Ginneken, Bart Liefers, Mark J J P van Grinsven, Sascha Fauser, Carel Hoyng, Thomas Theelen, Clara I Sánchez

Abstract read
In one paragraph

Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Freerk G VenhuizenDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.
Bram van GinnekenDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.
Bart LiefersDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.
Mark J J P van GrinsvenDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.
Sascha FauserRoche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Carel HoyngDepartment of Ophthalmology, Radboud University Medical Center, Nijmegen, the Netherlands.
Thomas TheelenDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.
Clara I SánchezDiagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed a fully automated system using a convolutional neural network (CNN) for total retina segmentation in optical coherence tomography (OCT) that is robust to the presence of severe retinal pathology. A generalized U-net network architecture was introduced to include the large context needed to account for large retinal changes. The proposed algorithm outperformed qualitative and quantitatively two available algorithms. The algorithm accurately estimated macular thickness with an error of 14.0 ± 22.1 µm, substantially lower than the error obtained using the other algorithms (42.9 ± 116.0 µm and 27.1 ± 69.3 µm, respectively). These results highlighted the proposed algorithm's capability of modeling the wide variability in retinal appearance and obtained a robust and reliable retina segmentation even in severe pathological cases.

Indexed as

(100.2960) Image analysis(100.4996) Pattern recognition, neural networks(110.4500) Optical coherence tomography(170.1610) Clinical applications(170.4470) Ophthalmology

Identifiers

PMID28717568
PMCPMC5508829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.