Evidence map›Paper›PMID 28717415›Full record

ArticleWorld journal of radiology2017

Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study.

Tamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Richard H C Lazeron, Paul A M Hofman, Anton J A de Louw, Walter H Backes, Jacobus F A Jansen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Clinical spectrum and treatment responses in.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Tamar M van VeenendaalTamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Paul A M Hofman, Walter H Backes, Jacobus FA Jansen, School for Mental Health and Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Dominique M IJffTamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Paul A M Hofman, Walter H Backes, Jacobus FA Jansen, School for Mental Health and Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Albert P AldenkampTamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Paul A M Hofman, Walter H Backes, Jacobus FA Jansen, School for Mental Health and Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Richard H C LazeronTamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Paul A M Hofman, Walter H Backes, Jacobus FA Jansen, School for Mental Health and Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Paul A M HofmanTamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Paul A M Hofman, Walter H Backes, Jacobus FA Jansen, School for Mental Health and Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Anton J A de LouwTamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Paul A M Hofman, Walter H Backes, Jacobus FA Jansen, School for Mental Health and Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Walter H BackesTamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Paul A M Hofman, Walter H Backes, Jacobus FA Jansen, School for Mental Health and Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Jacobus F A JansenTamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Paul A M Hofman, Walter H Backes, Jacobus FA Jansen, School for Mental Health and Neuroscience, Maastricht University, 6200 MD, Maastricht, The Netherlands.
Maastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug (AED) treatment.

methodsThe relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A "low risk" category (lamotrigine or levetiracetam,

resultsCentral information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant (

conclusionOnly the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects.

Indexed as

Antiepileptic drugsBrain networksCognitive side effectsFunctional magnetic resonance imagingGraph analysisResting state

Identifiers

PMID28717415
PMCPMC5491656
OpenAlexW2675130801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.