ArticleOxidative medicine and cellular longevity2017
Influence of the Microstructure and Silver Content on Degradation, Cytocompatibility, and Antibacterial Properties of Magnesium-Silver Alloys In Vitro.
Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 72 citations in OpenAlex.
- Experimental and Theoretical Investigation of theMaterials (Basel, Switzerland) · 2026Article
- Influence of Treated Surface Proportion on the Antibacterial Performance of UV-Activated Hydroxyapatite-Magnesium Phosphate-Zinc Oxide Coating on Magnesium Alloys.Journal of functional biomaterials · 2026Article
- Electrophoretic deposition of hydroxyapatite-capsaicin nanocomposite coatings on Mg-Ag alloy: effects on microstructure, hardness, and proliferation/chondrogenic differentiation of adipose-derived stem cells.Frontiers in bioengineering and biotechnology · 2026Article
- Antimicrobial Effects of Metal Coatings or Physical, Chemical Modifications of Titanium Dental Implant Surfaces for Prevention of Peri-Implantitis: A Systematic Review of In Vivo Studies.Antibiotics (Basel, Switzerland) · 2024Review
- Mg alloys with antitumor and anticorrosion properties for orthopedic oncology: A review from mechanisms to application strategies.APL bioengineering · 2024Review
- Development of a Bioreactor-Coupled Flow-Cell Setup for 3D In Situ Nanotomography of Mg Alloy Biodegradation.ACS applied materials & interfaces · 2023Article
- Magnesium-Based Temporary Implants: Potential, Current Status, Applications, and Challenges.Journal of functional biomaterials · 2023Review
- Anti-Virulence Strategy of Novel Dehydroabietic Acid Derivatives: Design, Synthesis, and Antibacterial Evaluation.International journal of molecular sciences · 2023Article
- Novel Study Antimicrobial and Biocompatibility Effect of Magnesium Silver Alloys 1% on Bovine Bacterial Species.Veterinary medicine international · 2023Article
- Influences of Extrusion and Silver Content on the Degradation of Mg-Ag AlloysBioinorganic chemistry and applications · 2022Article
- Antibacterial metals and alloys for potential biomedical implants.Bioactive materials · 2021Review
- Osteoinduction Evaluation of Fluorinated Hydroxyapatite and Tantalum Composite Coatings on Magnesium Alloys.Frontiers in chemistry · 2021Article
- Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials.Frontiers in cellular and infection microbiology · 2021Review
- Optimizing an Osteosarcoma-Fibroblast Coculture Model to Study Antitumoral Activity of Magnesium-Based Biomaterials.International journal of molecular sciences · 2020Article
- Proteome analysis of human mesenchymal stem cells undergoing chondrogenesis when exposed to the products of various magnesium-based materials degradation.Bioactive materials · 2019Article
- The Effect of Equal-Channel Angular Pressing on the Microstructure, the Mechanical and Corrosion Properties and the Anti-Tumor Activity of Magnesium Alloyed with Silver.Materials (Basel, Switzerland) · 2019Article
- The Effect of Surface Treatments on the Degradation of Biomedical Mg Alloys-A Review Paper.Materials (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantation is a frequent procedure in orthopedic surgery, particularly in the aging population. However, it possesses the risk of infection and biofilm formation at the surgical site. This can cause unnecessary suffering to patients and burden on the healthcare system. Pure Mg, as a promising metal for biodegradable orthopedic implants, exhibits some antibacterial effects due to the alkaline pH produced during degradation. However, this antibacterial effect may not be sufficient in a dynamic environment, for example, the human body. The aim of this study was to increase the antibacterial properties under harsh and dynamic conditions by alloying silver metal with pure Mg as much as possible. Meanwhile, the Mg-Ag alloys should not show obvious cytotoxicity to human primary osteoblasts. Therefore, we studied the influence of the microstructure and the silver content on the degradation behavior, cytocompatibility, and antibacterial properties of Mg-Ag alloys in vitro. The results indicated that a higher silver content can increase the degradation rate of Mg-Ag alloys. However, the degradation rate could be reduced by eliminating the precipitates in the Mg-Ag alloys via T4 treatment. By controlling the microstructure and increasing the silver content, Mg-Ag alloys obtained good antibacterial properties in harsh and dynamic conditions but had almost equivalent cytocompatibility to human primary osteoblasts as pure Mg.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.