Evidence map›Paper›PMID 28717404›Full record

ArticleEuropean review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity2017

Physical activity does not alter prolactin levels in post-menopausal women: results from a dose-response randomized controlled trial.

Darren R Brenner, Yibing Ruan, Andria R Morielli, Kerry S Courneya, Christine M Friedenreich

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01435005 (Breast Cancer and Exercise Trial in Alberta), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01435005 nacompletednot on this map

Breast Cancer and Exercise Trial in Alberta: The BETA Trial

TypeinterventionalSponsorAHS Cancer Control AlbertaRan2010 to 2014Enrolled400ConditionsBreast NeoplasmsArmsModerate Volume, High Volume
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Darren R BrennerDepartment of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 - 2nd St. SW, Calgary, AB T2S 3C3 Canada.
Yibing RuanDepartment of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 - 2nd St. SW, Calgary, AB T2S 3C3 Canada.
Andria R MorielliFaculty of Physical Education and Recreation University of Alberta, Edmonton, AB Canada.
Kerry S CourneyaFaculty of Physical Education and Recreation University of Alberta, Edmonton, AB Canada.
Christine M FriedenreichDepartment of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Holy Cross Centre, Room 513C, Box ACB, 2210 - 2nd St. SW, Calgary, AB T2S 3C3 Canada.
Alberta Health Services · CAUniversity of Alberta · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreased circulating levels of prolactin have been associated with increased risk of both in situ and invasive breast cancer. We investigated whether or not physical activity had a dose-response effect in lowering plasma levels of prolactin in postmenopausal women.

methodsFour hundred previously inactive but healthy postmenopausal women aged 50-74 years of age were randomized to 150 or 300 min per week of aerobic physical activity in a year-long intervention. Prolactin was measured from fasting samples with a custom-plex multiplex assay.

resultsA high compared to moderate volume of physical activity did not reduce plasma prolactin levels in intention-to-treat (Treatment Effect Ratio (TER) 1.00, 95% Confidence Interval (CI) 0.95 - 1.06) or per-protocol analyses (TER 1.02, 95% CI 0.93 - 1.13).

conclusionsIt is unlikely that changes in prolactin levels mediate the reduced risk of breast cancer development in post-menopausal women associated with increased levels of physical activity.

trial registrationclinicaltrials.gov identifier: NCT01435005.

Indexed as

Breast CancerPhysical ActivityProlactinRandomized Controlled Trial

Identifiers

PMID28717404
PMCPMC5508713
OpenAlexW2735376278

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.