Evidence map›Paper›PMID 28717401›Full record

ReviewTherapeutic advances in medical oncology2017

Novel therapeutic strategies in the treatment of triple-negative breast cancer.

Karima Oualla, Heba M El-Zawahry, Banu Arun, James M Reuben, Wendy A Woodward, Heba Gamal El-Din, Bora Lim, Nawfel Mellas, Naoto T Ueno, Tamer M Fouad

Abstract readReview
In one paragraph

Review in Therapeutic advances in medical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Comparative study of weekly and three-weekly neoadjuvant carboplatin in triple-negative breast cancer: retrospective analysis in real-world settings.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Novel applications of molecular imaging to guide breast cancer therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. The Antitriple Negative Breast cancer Efficacy ofOxidative medicine and cellular longevity · 2021
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Therapeutic advances in medical oncology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karima OuallaMedical Oncology Department, Hassan II University Hospital, Fes, Morocco.
Heba M El-ZawahryDepartment of Medical Oncology, The National Cancer Institute, Cairo University, Cairo, Egypt.
Banu ArunDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
James M ReubenDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wendy A WoodwardDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Heba Gamal El-DinDepartment of Surgical Oncology, The National Cancer Institute, Cairo University, Cairo, Egypt.
Bora LimDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, TX, USA.
Nawfel MellasMedical Oncology Department, Hassan II University Hospital, Fes, Morocco.
Naoto T UenoDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, TX, USA.
Tamer M FouadDepartment of Medical Oncology, The National Cancer Institute, Cairo University, Kasr El-Aini Road, Cairo, 11796, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that is defined by negative estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status. Treating patients with TNBC remains clinically challenging, as patients are not candidates for endocrine or HER2-directed therapy. As a result, chemotherapy with traditional agents such as anthracyclines and taxanes remains the only available option with moderate success. Recent discoveries have revealed that TNBC is a heterogeneous disease at the clinical, histological and molecular levels. The use of biomarkers to identify distinct subsets of TNBC that derive the greatest benefit from presently approved as well as novel therapeutics has become the main focus of current research. The aim of this review is to explore the clinical and biological complexity of TNBC as well as identify novel therapeutic options that target the various molecular subsets of TNBC.

Indexed as

chemotherapyclinical trialsimmunotherapymolecular subtypestargeted therapiestriple-negative breast cancer

Identifiers

PMID28717401
PMCPMC5502951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.