Evidence map›Paper›PMID 28717385›Full record

ArticleEvolutionary applications2017

Changes in diet associated with cancer: An evolutionary perspective.

Frédéric Thomas, Sophie Rome, Frédéric Mery, Erika Dawson, Jacques Montagne, Peter A Biro, Christa Beckmann, François Renaud, Robert Poulin, Michel Raymond and 1 more

Open access · goldAbstract read
In one paragraph

Article in Evolutionary applications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Oral nutritional supplement compliance among hospitalized cancer patients: a cross-sectional study based on the KAP model.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  3. Article
  4. Association of Fruit, Vegetable, and Animal Food Intakes with Breast Cancer Risk Overall and by Molecular Subtype among Vietnamese Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Frédéric ThomasCREEC/MIVEGEC UMR IRD/CNRS/UM 5290 Montpellier Cedex 5 France.ORCID 0000-0003-2238-1978
Sophie RomeCarMen (UMR INSERM 1060, INRA 1397, INSA) Faculté de Médecine Lyon-Sud Université de Lyon Oullins France.
Frédéric MeryEvolution, Génomes, Comportement and Ecologie CNRS, IRD Université Paris-Sud, Université Paris-Saclay Gif-sur-Yvette France.
Erika DawsonEvolution, Génomes, Comportement and Ecologie CNRS, IRD Université Paris-Sud, Université Paris-Saclay Gif-sur-Yvette France.
Jacques MontagneInstitute for Integrative Biology of the Cell (I2BC) CNRS Université Paris-Sud, CEA, UMR 9198 Gif-sur-Yvette France.
Peter A BiroCentre for Integrative Ecology School of Life and Environmental Sciences Deakin University Waurn Ponds VIC Australia.
Christa BeckmannCentre for Integrative Ecology School of Life and Environmental Sciences Deakin University Waurn Ponds VIC Australia.
François RenaudCREEC/MIVEGEC UMR IRD/CNRS/UM 5290 Montpellier Cedex 5 France.
Robert PoulinDepartment of Zoology University of Otago Dunedin New Zealand.
Michel RaymondInstitute of Evolutionary Sciences University of Montpellier Montpellier France.
Beata UjvariCentre for Integrative Ecology School of Life and Environmental Sciences Deakin University Waurn Ponds VIC Australia.ORCID 0000-0003-2391-2988
Deakin University · AUUniversité Paris-Sud · FRCentre National de la Recherche Scientifique · FRInstitut des Sciences de l'Evolution de Montpellier · FRUniversité Claude Bernard Lyon 1 · FRUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in diet are frequently correlated with the occurrence and progression of malignant tumors (i.e., cancer) in both humans and other animals, but an integrated conceptual framework to interpret these changes still needs to be developed. Our aim is to provide a new perspective on dietary changes in tumor-bearing individuals by adapting concepts from parasitology. Dietary changes may occur alongside tumor progression for several reasons: (i) as a pathological side effect with no adaptive value, (ii) as the result of self-medication by the host to eradicate the tumor and/or to slow down its progression, (iii) as a result of host manipulation by the tumor that benefits its progression, and finally (iv) as a host tolerance strategy, to alleviate and repair damages caused by tumor progression. Surprisingly, this tolerance strategy can be beneficial for the host even if diet changes are beneficial to tumor progression, provided that cancer-induced death occurs sufficiently late (i.e., when natural selection is weak). We argue that more data and a unifying evolutionary framework, especially during the early stages of tumorigenesis, are needed to understand the links between changes in diet and tumor progression. We argue that a focus on dietary changes accompanying tumor progression can offer novel preventive and therapeutic strategies against cancer.

Indexed as

malignant cellsmanipulationnutrition, self‐medicationresistance, tolerance

Identifiers

PMID28717385
PMCPMC5511355
OpenAlexW2587091325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.