ReviewFrontiers in neurology2017
Blood Pressure and Penumbral Sustenance in Stroke from Large Vessel Occlusion.
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 116 citations in OpenAlex.
- Prehospital neuroprotectant in combination with post-arrival thrombolytic therapy for acute ischemic stroke. Secondary analysis of the FAST-MAG prehospital trial.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026Trial
- Anaesthesia modality on endovascular therapy outcomes in patients with large infarcts: a post hoc analysis of the ANGEL-ASPECT trial.Stroke and vascular neurology · 2025Trial
- Association of Blood Pressure with Neurological Function Decline and Functional Outcome in Patients of Watershed Infarction.Neuropsychiatric disease and treatment · 2025Trial
- Blood pressure variation and futile recanalisation in patients with large-vessel occlusion after endovascular therapy.BMJ neurology open · 2026Article
- Intracerebral arterial blood pressure in the vasculature distal to large vessel occlusions in patients with ischemic stroke: correlation with clinical and imaging parameters.Journal of neurointerventional surgery · 2025Article
- Estimate the severity of acute ischemic stroke by optic nerve sheath ultrasound.The ultrasound journal · 2025Article
- Can CTA-Based Machine Learning Identify Patients for Whom Successful Endovascular Stroke Therapy Is Insufficient?AJNR. American journal of neuroradiology · 2025Article
- Recognizing and addressing the challenges of concomitant cerebrocardiac infarction.World journal of clinical cases · 2025Article
- Observational
- Non-Invasive Deep-Brain Imaging With 3D Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy (3D-PAULM).IEEE transactions on medical imaging · 2025Article
- Emergent endovascular treatment versus medical treatment for acute large vessel occlusions with nondisabling symptoms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Observational
- Association between short-term glucose fluctuations and cognition in patients with acute ischemic stroke complicated by type 2 diabetes mellitus.The journal of nutrition, health & aging · 2024Article
- Association between Transient-Continuous Hypotension during Mechanical Thrombectomy for Acute Ischemic Stroke and Final Infarct Volume in Patients with Proximal Anterior Circulation Large Vessel Occlusion.Journal of clinical medicine · 2024Article
- Article
- Functional Outcomes Associated With Blood Pressure Decrease After Endovascular Thrombectomy.JAMA network open · 2024Article
- Blood pressure variability and outcome in atherosclerosis versus cardioembolism cerebral large vessel occlusion after successful thrombectomy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Current and Emerging Endovascular and Neurocritical Care Management Strategies in Large-Core Ischemic Stroke.Journal of clinical medicine · 2023Review
- Preoperative Imaging Signs of Cerebral Malperfusion in Acute Type A Aortic Dissection: Influence on Outcomes and Prognostic Implications-A 20-Year Experience.Journal of clinical medicine · 2023Article
- Article
- Manual and Oscillometric Blood Pressure in tPA-Treated Acute Ischemic Stroke: What Constitutes Agreement?Stroke (Hoboken, N.J.) · 2023Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global burden of stroke remains high, and of the various subtypes of stroke, large vessel occlusions (LVOs) account for the largest proportion of stroke-related death and disability. Several randomized controlled trials in 2015 changed the landscape of stroke care worldwide, with endovascular thrombectomy (ET) now the standard of care for all eligible patients. With the proven success of this therapy, there is a renewed focus on penumbral sustenance. In this review, we describe the ischemic penumbra, collateral circulation, autoregulation, and imaging assessment of the penumbra. Blood pressure goals in acute stroke remain controversial, and we review the current data and suggest an approach for induced hypertension in the acute treatment of patients with LVOs. Finally, in addition to reperfusion and enhanced perfusion, efforts focused on developing therapeutic targets that afford neuroprotection and augment neural repair will gain increasing importance. ET has revolutionized stroke care, and future emphasis will be placed on promoting penumbral sustenance, which will increase patient eligibility for this highly effective therapy and reduce overall stroke-related death and disability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.