Evidence map›Paper›PMID 28717350›Full record

ArticleAdvanced functional materials2016

Properties of Native High-Density Lipoproteins Inspire Synthesis of Actively Targeted

Kaylin M McMahon, Michael P Plebanek, C Shad Thaxton

Abstract read
In one paragraph

Article in Advanced functional materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Radiolabeling lipoproteins to study and manage disease.European journal of nuclear medicine and molecular imaging · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Lipid carriers for mRNA delivery.Acta pharmaceutica Sinica. B · 2023
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Lipoprotein-based drug delivery.Advanced drug delivery reviews · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kaylin M McMahonDepartment of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA.
Michael P PlebanekDepartment of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA. Walter S. and Lucienne Driskill Graduate Training Program in Life Sciences, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA.
C Shad ThaxtonDepartment of Urology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA. Simpson Querrey Institute (SQI) for BioNanotechnology, Northwestern University, 303 East Superior, Chicago, IL 60611, USA. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior, Chicago, IL 60611, USA. International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
Northwestern University · USRobert H. Lurie Comprehensive Cancer Center of Northwestern University

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Theranostic Magnetic Nanostructures for the Molecular Imaging of CancerU54CA151880 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MEADE, THOMAS J · 2010 to 2014
$11.5M
CARCINOGENESIS TRAINING PROGRAMT32CA009560 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1986 to 2026
$8.4M
Basic Science Training Grant in UrologyT32DK062716 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLUMPP, DAVID J · 2003 to 2020
$2.0M
High Density Lipoprotein Nanoparticles for siRNA DeliveryR01CA167041 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI THAXTON, COLBY SHAD · 2012 to 2016
$1.6M
NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA167041NCI NIH HHS T32 CA009560NCI NIH HHS U54 CA151880NIDDK NIH HHS T32 DK062716
6 · The paper itself

Abstract

Efficient systemic administration of therapeutic short interfering RNA (siRNA) is challenging. High-density lipoproteins (HDL) are natural

Indexed as

active deliverylipoproteinnanoparticlesingle-strand RNAsiRNA

Identifiers

PMID28717350
PMCPMC5510894
OpenAlexW2521173037

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.