ArticleScientific reports2017
Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Trial
- Extensive particle size reduction of wheat bran increases the broiler's caecal fermentative capacity, but not bran fermentability ex vivo.Poultry science · 2026Article
- Insights into the Mechanisms of Action ofNutrients · 2024Review
- Impact of a Whole-Food, High-Soluble Fiber Diet on the Gut-Muscle Axis in Aged Mice.Nutrients · 2024Article
- A Review: Cereals on Modulating the Microbiota/Metabolome for Metabolic Health.Current nutrition reports · 2022Review
- Ferulic acid mediates prebiotic responses of cereal-derived arabinoxylans on host health.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Diet, microbiota, and the mucus layer: The guardians of our health.Frontiers in immunology · 2022Review
- Growth performance, visceral organ weights, and gut health of weaned pigs fed diets with different dietary fiber solubility and lipid sources.Journal of animal science · 2021Article
- Therapeutic Potential of Various Plant-Based Fibers to Improve Energy Homeostasis via the Gut Microbiota.Nutrients · 2021Review
- Multi-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice.Journal of cachexia, sarcopenia and muscle · 2021Article
- Effects of Wheat Bran andAnimals : an open access journal from MDPI · 2020Article
- Nutritional Status and the Influence of the Vegan Diet on the Gut Microbiota and Human Health.Medicina (Kaunas, Lithuania) · 2020Review
- Dietary Xanthan Gum Alters Antibiotic Efficacy against the Murine Gut Microbiota and AttenuatesmSphere · 2020Article
- The Effect of Xylooligosaccharide, Xylan, and Whole Wheat Bran on the Human Gut Bacteria.Frontiers in microbiology · 2020Article
- Maize Bran Particle Size Governs the Community Composition and Metabolic Output of Human Gut Microbiota inFrontiers in microbiology · 2020Article
- Maternal Exercise Improves High-Fat Diet-Induced Metabolic Abnormalities and Gut Microbiota Profiles in Mouse Dams and Offspring.Frontiers in cellular and infection microbiology · 2020Article
- The Janus Face of Cereals: Wheat-Derived Prebiotics Counteract the Detrimental Effect of Gluten on Metabolic Homeostasis in Mice Fed a High-Fat/High-Sucrose Diet.Molecular nutrition & food research · 2019Article
- Chitin-glucan and pomegranate polyphenols improve endothelial dysfunction.Scientific reports · 2019Article
- Divergent short-chain fatty acid production and succession of colonic microbiota arise in fermentation of variously-sized wheat bran fractions.Scientific reports · 2018Article
- Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The aim of this study was to determine the impact of different wheat bran fractions on the gut microbiota and fat binding capacity to explain their differential effects on metabolic and inflammatory disorders induced by a western diet (WD) in mice. Wheat bran derived arabinoxylan oligosaccharides (AXOS), a crude fraction of wheat bran (WB), or the same wheat bran with reduced particle size (WBs) were added to the WD of mice for 8 weeks. AXOS shifted the gut microbiota composition, blunted Clostridium and Turicibacter genera and strongly promoted Bifidobacterium and Butyricicoccus genera, independently of changes in gut antimicrobial peptide expression. AXOS was the most efficient to reduce adiposity. Only WB fraction promoted fat excretion and differed from the other fractions by the capacity to increase the Akkermansia genus and to counteract gut interleukin 1 beta (IL1β) overexpression. Strikingly, WBs promoted steatosis and adipose tissue inflammation, despite its ability -like WB- to increase bacterial diversity. In conclusion, wheat bran fractions differently affect metabolic and inflammatory disorders associated with WD feeding, depending on their particle size, their fat binding capacity and their influence on the gut microbiota. Those results might be useful to take into account in nutritional advices to control obesity.
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