ArticleScientific reports2017
A clinicopathological analysis of 153 acral melanomas and the relevance of mechanical stress.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Malignant Melanoma Misdiagnosis in the Diabetic Foot. What Can We Learn From the Published Literature?Journal of foot and ankle research · 2026Pooled it
- Risk factors for the development of acral melanoma: A multi-institutional, retrospective cohort study.JAAD international · 2026Article
- Unmet needs and associated factors among patients with melanoma: a mixed-methods study.Frontiers in public health · 2026Article
- Article
- Association of Weight-Bearing Activity and Prognosis of Plantar Melanoma: An Unanticipated Perspective.Annals of surgical oncology · 2025Article
- Survival Outcomes of a Large Cohort of Acral Melanoma Patients Treated at a South African Referral Hospital.Journal of skin cancer · 2025Article
- In Vivo Reflectance Confocal Microscopy Applied to Acral Melanocytic Lesions: A Systematic Review of the Literature.Diagnostics (Basel, Switzerland) · 2024Review
- Acral Melanoma Incidence and Survival Trends in 1990-2020: A Nationwide, Population-based Study.Acta dermato-venereologica · 2024Article
- The genetic evolution of acral melanoma.Nature communications · 2024Article
- Pressure and Skin: A Review of Disease Entities Driven or Influenced by Mechanical Pressure.American journal of clinical dermatology · 2024Review
- Molecular Profile of Subungual Melanoma: A MelaNostrum Consortium Study of 68 Cases Reporting BRAF, NRAS, KIT, and TERT Promoter Status.Dermatology (Basel, Switzerland) · 2024Article
- Management of acral lentiginous melanoma: current updates and future directions.Frontiers in oncology · 2024Review
- Validation of a Dermatoscopy-Based Algorithm for the Diagnosis of Acral Melanoma.Dermatology (Basel, Switzerland) · 2024Article
- The genetic evolution of acral melanoma.bioRxiv : the preprint server for biology · 2023Article
- Nail Apparatus Melanoma: Current Management and Future Perspectives.Journal of clinical medicine · 2023Review
- Histopathological Characteristics and Prognosis of Malignant Acral Melanomas in Pakistani Patients.Cureus · 2023Article
- Article
- Promotion of Melanoma Cell Proliferation by Cyclic Straining through Regulatory Morphogenesis.International journal of molecular sciences · 2022Article
- Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis.Nature communications · 2022Article
- More than just acral melanoma: the controversies of defining the disease.The journal of pathology. Clinical research · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of melanomas emerging in plantar surfaces remains unclear; however, mechanical stress has been reported to increase the formation of melanomas. In this study, we conducted a multicenter retrospective analysis of 153 acral melanomas diagnosed between 2000 and 2015 in Taiwan. The male-to-female ratio of the patients in question was 1:1.28, and the mean age at diagnosis was 68 years. We examined whether melanomas which developed in different areas of the patients' soles differed in their associations with various clinicopathological characteristics and survival. Testing by goodness of fit indicated that stress-bearing areas were significantly more conducive to the generation of melanomas than non-stress-bearing areas (P < 0.0001). More specifically, compared to the arch, the rear of the foot and front of the foot were significantly more conducive to the generation of melanomas (P < 0.0001 and P < 0.0001, respectively). The distribution pattern was not associated with differences in age, gender, right/left foot involvement, ulceration, mitosis, lymph node metastasis, tumor thickness, or stage. The overall, distant metastasis-free, and recurrence-free survival rates did not differ significantly between the stress-bearing and non-stress-bearing areas. Furthermore, while acral melanomas tended to develop on stress-bearing areas, the distribution pattern was not associated with the prognostic index or survival.
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