ArticleScientific reports2017
An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Paediatric obesity: a systematic review and pathway mapping of metabolic alterations underlying early disease processes.Molecular medicine (Cambridge, Mass.) · 2021Pooled it
- Gut microbiota profile in school-aged children with vitamin A depletion and vitamin E deficiency: A cross-sectional study.Gut microbes reports · 2027Article
- Development and Validation of a Targeted Metabolomic Tool for Metabotype Classification in Schoolchildren.Metabolites · 2026Article
- P2-HNF4α alters linoleic acid metabolism and mitigates soybean oil-induced obesity: role for oxylipins.Journal of lipid research · 2025Article
- Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control.Nature metabolism · 2025Article
- Serum tyrosine increases all-cause mortality in an older population.Frontiers in endocrinology · 2025Article
- Association of Whole Blood Amino Acid and Acylcarnitine Metabolome with Anthropometry and IGF-I Serum Levels in Healthy Children and Adolescents in Germany.Metabolites · 2024Article
- The metabolic signature of blood lipids: a causal inference study using twins.Journal of lipid research · 2024Article
- Valine induces inflammation and enhanced adipogenesis in lean mice by multi-omics analysis.Frontiers in nutrition · 2024Article
- Examining Maternal Cardiometabolic Markers in Pregnancy on Child Emotional and Behavior Trajectories: Using Growth Curve Models on a Cohort Study.Biological psychiatry global open science · 2023Article
- Metabolomic Characteristics of Cecum Contents in High-Fat-Diet-Induced Obese Mice Intervened with Different Fibers.Foods (Basel, Switzerland) · 2023Article
- Effect of Frozen-Thawed Embryo Transfer on the Metabolism of Children in Early Childhood.Journal of clinical medicine · 2023Article
- The Potential of Metabolomics in Biomedical Applications.Metabolites · 2022Review
- Metabolic features of adiposity and glucose homoeostasis among school-aged inuit children from Nunavik (Northern Quebec, Canada).International journal of circumpolar health · 2021Article
- Evaluating the direct effects of childhood adiposity on adult systemic metabolism: a multivariable Mendelian randomization analysis.International journal of epidemiology · 2021Article
- Article
- A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents.Molecular medicine (Cambridge, Mass.) · 2021Article
- Impact of lifestyle Intervention on branched-chain amino acid catabolism and insulin sensitivity in adolescents with obesity.Endocrinology, diabetes & metabolism · 2021Article
- Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation.GeroScience · 2021Article
- Plasma Amino Acids and Residual Hypertriglyceridemia in Diabetic Patients Under Statins: Two Independent Cross-Sectional Hospital-Based Cohorts.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascular risk. Metabolites can be useful as early biomarkers and new targets to promote early intervention beginning in school age. Thus, we aimed to identify metabolomic profiles associated with obesity and obesity-related metabolic traits. We used data from the Obesity Research Study for Mexican children (ORSMEC) in Mexico City and included a case control (n = 1120), cross-sectional (n = 554) and a longitudinal study (n = 301) of 6-12-year-old children. Forty-two metabolites were measured using electrospray MS/MS and multivariate regression models were used to test associations of metabolomic profiles with anthropometric, clinical and biochemical parameters. Principal component analysis showed a serum amino acid signature composed of arginine, leucine/isoleucine, phenylalanine, tyrosine, valine and proline significantly associated with obesity (OR = 1.57; 95%CI 1.45-1.69, P = 3.84 × 10
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