ArticleScientific reports2017
Cognitive brain responses during circadian wake-promotion: evidence for sleep-pressure-dependent hypothalamic activations.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Functional brain alterations in acute sleep deprivation: An activation likelihood estimation meta-analysis.Sleep medicine reviews · 2019Pooled it
- Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men.Journal of biological rhythms · 2021Trial
- Uncorrelated Age-Related Changes in Visuo-Spatial Working Memory Binding and Thermoregulation.Clocks & sleep · 2025Article
- Sleep parameters improvement in PTSD soldiers after symptoms remission.Scientific reports · 2021Article
- Sleep and Attention in Alzheimer's Disease.The Yale journal of biology and medicine · 2019Review
- Non-REM Sleep Characteristics Predict Early Cognitive Impairment in an Aging Population.Frontiers in neurology · 2019Article
- The alerting effect of the wake maintenance zone during 40 hours of sleep deprivation.Scientific reports · 2018Article
- Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement.Scientific reports · 2018Article
- TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom.Frontiers in neuroscience · 2018Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The two-process model of sleep-wake regulation posits that sleep-wake-dependent homeostatic processes interact with the circadian timing system to affect human behavior. The circadian timing system is fundamental to maintaining stable cognitive performance, as it counteracts growing homeostatic sleep pressure during daytime. Using magnetic resonance imaging, we explored brain responses underlying working memory performance during the time of maximal circadian wake-promotion under varying sleep pressure conditions. Circadian wake-promoting strength was derived from the ability to sleep during an evening nap. Hypothalamic BOLD activity was positively linked to circadian wake-promoting strength under normal, but not under disproportionally high or low sleep pressure levels. Furthermore, higher hypothalamic activity under normal sleep pressure levels predicted better performance under sleep loss. Our results reappraise the two-process model by revealing a homeostatic-dose-dependent association between circadian wake-promotion and cognition-related hypothalamic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.