ArticleScientific reports2017
Patterned Arrangements of Olfactory Receptor Gene Expression in Zebrafish are Established by Radial Movement of Specified Olfactory Sensory Neurons.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Mechanical constraints on cell plasticity: insights from the olfactory epithelium.Frontiers in cell and developmental biology · 2026Review
- Structural Regeneration and Functional Recovery of the Olfactory System of Adult Zebrafish Following Brain Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A pheromone receptor in cichlid fish mediates attraction to females but inhibits male parental care.Current biology : CB · 2024Article
- Molecular Characterization of Neurogranin (NRGN) Gene from Red‑Bellied Pacu (Piaractus brachypomus).Molecular neurobiology · 2024Article
- Ancient and Nonuniform Loss of Olfactory Receptor Expression Renders the Shark Nose a De Facto Vomeronasal Organ.Molecular biology and evolution · 2023Article
- Spatial organization of olfactory receptor gene choice in the complete V1R-related ORA family of zebrafish.Scientific reports · 2022Article
- Disparate progenitor cell populations contribute to maintenance and repair neurogenesis in the zebrafish olfactory epithelium.Cell and tissue research · 2022Article
- A protocol to evaluate epithelial regeneration after inducing cell loss in zebrafish larvae.STAR protocols · 2022Article
- The Olfactory Organ Is a Unique Site for Neutrophils in the Brain.Frontiers in immunology · 2022Article
- An Ancient Adenosine Receptor Gains Olfactory Function in Bony Vertebrates.Genome biology and evolution · 2021Article
- Diving into the streams and waves of constitutive and regenerative olfactory neurogenesis: insights from zebrafish.Cell and tissue research · 2021Review
- The Olfactory System of Zebrafish as a Model for the Study of Neurotoxicity and Injury: Implications for Neuroplasticity and Disease.International journal of molecular sciences · 2019Review
- Overlapping but distinct topology for zebrafish V2R-like olfactory receptors reminiscent of odorant receptor spatial expression zones.BMC genomics · 2018Article
- Comprehensive Identification and Spatial Mapping of Habenular Neuronal Types Using Single-Cell RNA-Seq.Current biology : CB · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatial restriction of olfactory receptor (OR) gene expression in peripheral sense organs is a common phenomenon across species, suggesting that zonal OR expression somehow contributes to olfactory function. In zebrafish OR expression patterns reminiscent of zones occur as concentric domains with preferred diameters for different ORs. However, the function and the developmental origin of the pattern are unknown. Here we investigate olfactory sensory neuron (OSN) neurogenesis in the adult zebrafish olfactory epithelium (OE) to understand how the zonally organized OR pattern is established and maintained during the lifetime of the animal. We find that OSNs are generated from two discontinuous proliferation zones located at the central and peripheral edge of the sensory OE. OSNs turn on OR expression soon after they exit mitosis and invade the sensory tissue, approaching each other from both ends of the OE. Biased generation of OSN subpopulations at both neurogenic sites and elimination of OSNs along their route across the OE generates the impression of OR-specific expression domains. We formulated a simple mathematical model based on exact parameters derived from our analysis of OSN neurogenesis, which accurately generates OR-like distributions without the need to invoke molecular signals to pattern the OE.
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