ArticleScientific reports2017
Relationship between Retinal Inner Nuclear Layer Thickness and Severity of Visual Field Loss in Glaucoma.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The impact of disc hemorrhage studies on our understanding of glaucoma: a systematic review 50 years after the rediscovery of disc hemorrhage.Japanese journal of ophthalmology · 2019Pooled it
- Diagnostic Potential of Ganglion Cell Layer to Inner Plexiform Layer Thickness Ratio in Distinguishing Branch Retinal Vein Occlusion from Primary Open-Angle Glaucoma.Research square · 2026Article
- Associations between retinal morphological features and risk of depression and anxiety disorders.BMC medicine · 2026Article
- Retinomics as a Tool for Glaucoma Prediction.Ophthalmology science · 2026Article
- Characterizing Retinal Mitochondrial Function and Its Relations to Intraretinal Thicknesses in Healthy Adults.Current eye research · 2025Article
- Macular Optical Coherence Tomography Parameters and Incident Glaucoma Among Myopic Eyes.Translational vision science & technology · 2025Observational
- Retinal and Choriocapillaris Thickness Changes in Spontaneously Diabetic Macaques.Investigative ophthalmology & visual science · 2025Article
- Development of Microcystoid Macular Degeneration in the Retina of Nonhuman Primates: Time-Course and Associated Pathologies.Current eye research · 2025Article
- Thicker Inner Nuclear Layer as a Predictor of Glaucoma Progression and the Impact of Intraocular Pressure Fluctuation.Journal of clinical medicine · 2024Article
- Automated macular segmentation can distinguish glaucomatous from compressive optic neuropathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Observational
- Beneficial and Detrimental Pressure-Related Effects on Inner Neurons in the Adult Porcine In Vitro Retina.Translational vision science & technology · 2023Article
- Characterizing macular edema in retinitis pigmentosa through a combined structural and microvascular optical coherence tomography investigation.Scientific reports · 2023Observational
- High sampling resolution optical coherence tomography reveals potential concurrent reductions in ganglion cell-inner plexiform and inner nuclear layer thickness but not in outer retinal thickness in glaucoma.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- The thickness of the outer retina in the macula and circumpapillary area in patients with unilateral advanced glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Relationship Between Deep Retinal Macular Vessel Density and Bipolar Cell Function in Glaucomatous Eyes.Translational vision science & technology · 2022Article
- Superficial and Deep Macula Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.Journal of glaucoma · 2021Article
- PathogenicBrain communications · 2021Article
- DeepRetina: Layer Segmentation of Retina in OCT Images Using Deep Learning.Translational vision science & technology · 2020Article
- Longitudinal outcomes of circumlimbal suture model-induced chronic ocular hypertension in Sprague-Dawley albino rats.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- Segmented retinal layer analysis of chiasmal compressive optic neuropathy in pituitary adenoma patients.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glaucoma is a disease characterized by pathologic changes in inner retinal layers, which are comprised of retinal ganglion cells (RGCs). As retinal ganglion cells (RGCs) cross over other retinal neurons that are connected by synapses, it is meaningful to investigate the outer retinal changes in glaucoma. We evaluated the association between thicknesses of segmented retinal layers in macular region and severity of visual field loss in open-angle glaucoma (OAG). This study involved 103 glaucomatous eyes. Retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL) thicknesses were measured at the macular level using the Spectral-domain optical coherence tomography with segmentation software. The functional losses were measured using 24-2 standard automated perimetry. Macular structure losses were positively correlated with functional loss for RNFL, GCL, and IPL (R = 0.550, 0.637, and 0.649, respectively, P < 0.001) and negatively correlated with INL (R = -0.295, P = 0.041). By multivariate regression analysis, INL thickness was significantly associated with visual field mean deviation (dB) and optic disc hemorrhage. These finding carefully suggest reactive responses of neuronal or glial cells located in the INL occur during glaucoma progression.
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