Evidence map›Paper›PMID 28717082›Full record

ArticleInternal medicine (Tokyo, Japan)2017

Post-cytokine-release Salt Wasting as Inverse Tumor Lysis Syndrome in a Non-cerebral Natural Killer-cell Neoplasm.

Hirotsugu Ariizumi, Yosuke Sasaki, Hiroshi Harada, Yui Uto, Remi Azuma, Tomohide Isobe, Koji Kishimoto, Eisuke Shiozawa, Masafumi Takimoto, Nobuyuki Ohike and 1 more

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Tumour lysis syndrome.Nature reviews. Disease primers · 2024
    Review
  2. Hyponatremia in Patients with Hematologic Diseases.Journal of clinical medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hirotsugu AriizumiDepartment of Hematology, Showa University Fujigaoka Hospital, Japan.
Yosuke SasakiDepartment of Pathology, Showa University School of Medicine, Japan.
Hiroshi HaradaDepartment of Hematology, Showa University Fujigaoka Hospital, Japan.
Yui UtoDepartment of Hematology, Showa University Fujigaoka Hospital, Japan.
Remi AzumaDepartment of Hematology, Showa University Fujigaoka Hospital, Japan.
Tomohide IsobeDepartment of Pathology, Showa University Fujigaoka Hospital, Japan.
Koji KishimotoDepartment of Pathology, Showa University Fujigaoka Hospital, Japan.
Eisuke ShiozawaDepartment of Pathology, Showa University School of Medicine, Japan.
Masafumi TakimotoDepartment of Pathology, Showa University School of Medicine, Japan.
Nobuyuki OhikeDepartment of Pathology, Showa University Fujigaoka Hospital, Japan.
Hiraku MoriDepartment of Hematology, Showa University Fujigaoka Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of cerebral/renal salt-wasting syndrome remains unknown. We herein present a case of salt-wasting syndrome with a natural killer-cell neoplasm without cerebral invasion. A 78-year-old man with hemophagocytic syndrome received two cycles of chemotherapy that did not induce tumor lysis syndrome, but repeatedly caused polyuria and natriuresis. The expression of tumor necrosis factor-α in the neoplasm led us to hypothesize that an oncolysis-induced cytokine storm may have caused renal tubular damage and salt wasting. Our theory may explain the pathogenic mechanism of cerebral/renal salt-wasting syndrome associated with other entities, including cerebral disorders, owing to the elevation of cytokine levels after subarachnoid hemorrhage.

Indexed as

AgedAntineoplastic Combined Chemotherapy ProtocolsCytokinesHumansHyponatremiaInappropriate ADH SyndromeLeukemia, Large Granular LymphocyticMaleNatriuresisPolyuriaTumor Lysis SyndromeCytokinescerebral salt wasting syndromepathogenesispathophysiologyrenal salt wasting syndrometumor necrosis factor-alpha

Identifiers

PMID28717082
PMCPMC5548679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.