Evidence map›Paper›PMID 28717006›Full record

ArticleThe Journal of biological chemistry2017

Extrinsic sialylation is dynamically regulated by systemic triggers

Charles T Manhardt, Patrick R Punch, Christopher W L Dougher, Joseph T Y Lau

Open access · hybridAbstract readComparative Study
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Sialylation in the nervous system: Functions and mechanisms.The Journal of biological chemistry · 2026
    Review
  3. Article
  4. Article
  5. Role of Antibody Glycosylation in Health, Disease, and Therapy.Handbook of experimental pharmacology · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Complement, Coagulation, and Fibrinolysis: The Role of the Endothelium and Its Glycocalyx Layer in Xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Charles T ManhardtFrom the Departments of Molecular and Cellular Biology and.
Patrick R PunchFrom the Departments of Molecular and Cellular Biology and.
Christopher W L DougherImmunology, Roswell Park Cancer Institute, Buffalo, New York 14263.
Joseph T Y LauFrom the Departments of Molecular and Cellular Biology and joseph.lau@roswellpark.org.
Roswell Park Comprehensive Cancer Center · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
REGULATION OF LACTOSAMINYL GLYCAN BIOSYNTHESIS IN HEMATOPOIETIC CELLSP01HL107146 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LAU, JOSEPH TY · 2011 to 2017
$17.7M
ST6Gal-1 Sialyltransferase in InflammationR01AI140736 · NIAID · ROSWELL PARK CANCER INSTITUTE CORP · PI LAU, JOSEPH TY · 2018 to 2021
$3.9M
ST6Gal Sialyltransferase in Innate and Adaptive Immune ResponseR01AI056082 · NIAID · ROSWELL PARK CANCER INSTITUTE CORP · PI LAU, JOSEPH TY · 2006 to 2015
$3.6M
NCI NIH HHS P30 CA016056NHLBI NIH HHS P01 HL107146NIAID NIH HHS R01 AI056082NIAID NIH HHS R01 AI140736
6 · The paper itself

Abstract

Recent reports have documented that extracellular sialyltransferases can remodel both cell-surface and secreted glycans by a process other than the canonical cell-autonomous glycosylation that occurs within the intracellular secretory apparatus. Despite association of the abundance of these extracellular sialyltransferases, particularly ST6Gal-1, with disease states such as cancer and a variety of inflammatory conditions, the prevalence of this extrinsic glycosylation pathway

Indexed as

Disease Models, AnimalProtein Processing, Post-TranslationalAnimalsbeta-D-Galactoside alpha 2-6-SialyltransferaseBiomarkersBlood PlateletsBone Marrow CellsMesenteric ArteriesMice, Inbred C57BLMice, KnockoutMixed Function OxygenasesPlatelet ActivationSialyltransferasesSystemic Inflammatory Response SyndromeThrombosisbeta-D-Galactoside alpha 2-6-SialyltransferaseBiomarkersCMPacetylneuraminate monooxygenaseMixed Function OxygenasesSialyltransferasesCMAHinflammationNeu5Gcplateletplateletssialic acidsialylationsialyltransferaseST6Gal-1thrombosis

Identifiers

PMID28717006
PMCPMC5566511
OpenAlexW2735691045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.