ArticleLearning & memory (Cold Spring Harbor, N.Y.)2017
Acute exercise enhances the consolidation of fear extinction memory and reduces conditioned fear relapse in a sex-dependent manner.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Renewal of conditioned fear in a third context after either extinction or counterconditioning: Testing the effects of sex and hormones.Behavioral neuroscience · 2026Article
- Estrous Cycle Impacts Fear Extinction and Relapse in Female Adolescent Rats.Developmental psychobiology · 2025Article
- High ovarian hormones present during fear extinction reduce fear relapse through a nigrostriatal dopamine pathway.Biology of sex differences · 2025Article
- Renewal of conditioned fear in male and female rats.Behavioral neuroscience · 2024Article
- Pharmacological manipulations of the dorsomedial and dorsolateral striatum during fear extinction reveal opposing roles in fear renewal.Neurobiology of learning and memory · 2024Article
- Microglia are necessary for probiotics supplementation to improve impaired fear extinction caused by pregnancy stress in adult offspring of rats.Neurobiology of stress · 2024Article
- Exercise and Fear and Safety Learning.Current topics in behavioral neurosciences · 2024Review
- Sex differences in avoidance behavior and cued threat memory dynamics in mice: Interactions between estrous cycle and genetic background.Hormones and behavior · 2023Article
- Aerobic exercise in the treatment of PTSD: An examination of preclinical and clinical laboratory findings, potential mechanisms, clinical implications, and future directions.Journal of anxiety disorders · 2023Review
- Potential resilience treatments for orangutans (Animal welfare (South Mimms, England) · 2023Article
- Duration- and sex-dependent neural circuit control of voluntary physical activity.Psychopharmacology · 2022Article
- Sex-dependent effects of chronic exercise on cognitive flexibility but not hippocampal Bdnf in aging mice.Neuronal signaling · 2022Review
- Sex differences in the immediate extinction deficit and renewal of extinguished fear in rats.PloS one · 2022Article
- Hippocampal neurogenesis mediates sex-specific effects of social isolation and exercise on fear extinction in adolescence.Neurobiology of stress · 2021Article
- Acute exercise enhances fear extinction through a mechanism involving central mTOR signaling.Neurobiology of learning and memory · 2020Article
- Compensatory eating behaviors in male and female rats in response to exercise training.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- The neurobiological basis of sex differences in learned fear and its inhibition.The European journal of neuroscience · 2020Review
- Sex differences in resilience: Experiential factors and their mechanisms.The European journal of neuroscience · 2020Review
- Voluntary exercise enables stress resistance in females.Behavioural brain research · 2019Article
- Acute exercise-induced enhancement of fear inhibition is moderated by BDNF Val66Met polymorphism.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Fear extinction-based exposure therapy is the most common behavioral therapy for anxiety and trauma-related disorders, but fear extinction memories are labile and fear tends to return even after successful extinction. The relapse of fear contributes to the poor long-term efficacy of exposure therapy. A single session of voluntary exercise can enhance the acquisition and consolidation of fear extinction in male rats, but the effects of exercise on relapse of fear after extinction are not well understood. Here, we characterized the effects of 2 h of voluntary exercise during the consolidation phase of contextual or auditory fear extinction learning on long-term fear extinction memory and renewal in adult, male and female, Long-Evans rats. Results indicate that exercise enhances consolidation of fear extinction memory and reduces fear relapse after extinction in a sex-dependent manner. These data suggest that brief bouts of exercise could be used as an augmentation strategy for exposure therapy, even in previously sedentary subjects. Fear memories of discrete cues, rather than of contextual ones, may be most susceptible to exercise-augmented extinction, especially in males. Additionally, exercise seems to have the biggest impact on fear relapse phenomena, even if fear extinction memories themselves are only minimally enhanced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.