Evidence map›Paper›PMID 28716936›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Bacterial infection imaging with [

Mark A Sellmyer, Iljung Lee, Catherine Hou, Chi-Chang Weng, Shihong Li, Brian P Lieberman, Chenbo Zeng, David A Mankoff, Robert H Mach

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. BMC oral health · 2026
    Article
  4. Radiolabeled Antimicrobials for Infection Imaging: A Scoping Review.International journal of molecular sciences · 2026
    Article
  5. Review
  6. Influence of Subcellular Localization on the Cytotoxicity of Targeted α-Therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  7. First-in-Human Biodistribution and Dosimetry of [Molecular imaging and biology · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Automated radiosynthesis of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025
    Article
  12. Automated radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mark A SellmyerDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104 mark.sellmyer@uphs.upenn.edu rmach@mail.med.upenn.edu.ORCID 0000-0002-1407-1905
Iljung LeeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Catherine HouDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Chi-Chang WengDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Shihong LiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Brian P LiebermanDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Chenbo ZengDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
David A MankoffDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Robert H MachDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104 mark.sellmyer@uphs.upenn.edu rmach@mail.med.upenn.edu.
University of Pennsylvania · US

Funding

RESEARCH TRACK RADIOLOGY RESIDENCYT32EB004311 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Terence P Gade, Misun Hwang · 2005 to 2026
$4.5M
NIBIB NIH HHS T32 EB004311
6 · The paper itself

Abstract

There is often overlap in the diagnostic features of common pathologic processes such as infection, sterile inflammation, and cancer both clinically and using conventional imaging techniques. Here, we report the development of a positron emission tomography probe for live bacterial infection based on the small-molecule antibiotic trimethoprim (TMP). [

Indexed as

AnimalsAnti-Bacterial AgentsCell LineDisease Models, AnimalEscherichia coliEscherichia coli InfectionsFluorine RadioisotopesHCT116 CellsHumansMacaca mulattaMiceMice, Inbred BALB CMicrobial Sensitivity TestsPositron-Emission TomographyPseudomonas aeruginosaPseudomonas InfectionsAnti-Bacterial AgentsFluorine-18Fluorine RadioisotopesRadiopharmaceuticalsTrimethoprimbacteriaimagingPETradiotracertrimethoprim

Identifiers

PMID28716936
PMCPMC5547613
OpenAlexW2735303761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.