Evidence map›Paper›PMID 28716915›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.

Annavarapu Hari Kishore, Hanquan Liang, Mohammed Kanchwala, Chao Xing, Thota Ganesh, Yucel Akgul, Bruce Posner, Joseph M Ready, Sanford D Markowitz, Ruth Ann Word

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Prostaglandin EEXCLI journal · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Immunobiology of Cervix Ripening.Frontiers in immunology · 2019
    Review
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Annavarapu Hari KishoreThe Cecil H. and Ida Green Center for Reproductive Biology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Hanquan LiangEugene McDermott Center for Human Growth & Development and Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Mohammed KanchwalaEugene McDermott Center for Human Growth & Development and Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-6035-2970
Chao XingEugene McDermott Center for Human Growth & Development and Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Thota GaneshDepartment of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322.
Yucel AkgulDepartment of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Bruce PosnerDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Joseph M ReadyDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Sanford D MarkowitzDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Ruth Ann WordThe Cecil H. and Ida Green Center for Reproductive Biology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390; ruth.word@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · USEmory University · USUniversity Hospitals of Cleveland · US

Funding

UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Molecular and Genomic Mechanisms in the Biology of Pregnancy and ParturitionP01HD087150 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI FLORIAN-RODRIGUEZ, MARIA, MAHENDROO, MALA S. · 2017 to 2021
$6.7M
Targeting 15-Prostaglandin Dehydrogenase (15-PGDH) in Cancer Risk, Prevention, and TreatmentR35CA197442 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2017 to 2023
$6.6M
Chemical Inhibitors of 15-prostaglandin dehydrogenase Potentiate Hematopoietic Stem Cell TransplantationR01CA216863 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GERSON, STANTON L., MARKOWITZ, SANFORD D. · 2017 to 2019
$1.9M
Mechanisms of Prostaglandin-induced Cervical Ripening in HumansR01HD080776 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI WORD, RUTH A · 2015 to 2019
$1.7M
Cervical Ripening and Histone AcetylationR21HD082502 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI WORD, RUTH A · 2015 to 2016
$443k
NCATS NIH HHS UL1 TR001105NCI NIH HHS R01 CA216863NCI NIH HHS R35 CA197442NICHD NIH HHS P01 HD087150NICHD NIH HHS R01 HD080776NICHD NIH HHS R21 HD082502
6 · The paper itself

Abstract

The cervix represents a formidable structural barrier for successful induction of labor. Approximately 10% of pregnancies undergo induction of cervical ripening and labor with prostaglandin (PG) E

Indexed as

AnimalsCalciumCell LineCervical RipeningCervix UteriCyclooxygenase 2DinoprostoneDown-RegulationFemaleHistone Deacetylase 2Histone DeacetylasesHumansHydroxyprostaglandin DehydrogenasesMiceMice, Inbred C57BLPregnancy15-hydroxyprostaglandin dehydrogenaseCalciumCyclooxygenase 2DinoprostoneHDAC2 protein, humanHDAC4 protein, humanHDAC5 protein, humanHistone Deacetylase 2Histone DeacetylasesHydroxyprostaglandin DehydrogenasesProstaglandin-E SynthasesPTGES protein, humanPTGS2 protein, humanReceptors, Prostaglandin E, EP2 SubtypeRepressor ProteinsRNA, Small Interferingcervical shorteningHDAC4labor inductionpreterm laborprostaglandin E2

Identifiers

PMID28716915
PMCPMC5547630
OpenAlexW2736198424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.