ArticleProceedings of the National Academy of Sciences of the United States of America2017
Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
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Who cites it
69 citing papers in PubMed, 118 citations in OpenAlex.
- Immune thrombocytopenia in patients with connective tissue disease.Clinical rheumatology · 2026Review
- Molecular Survival Strategies Against Kidney Filtration: Implications for Therapeutic Protein Engineering.Biophysica · 2026Article
- Kupffer cells are essential for platelet-mediated thrombopoietin generation in the liver.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Highly variable aggregation and glycosylation profiles and their roles in immunogenicity to protein-based therapeutics.Journal of pharmaceutical sciences · 2025Review
- Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs.ACS chemical biology · 2025Article
- The C3/C3aR pathway exacerbates acetaminophen-induced mouse liver injury via upregulating podoplanin on the macrophage.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- A Novel Missense Variant in Ultrarare SLC35A1-CDG Alters Cellular Glycosylation, Lipid, and Energy Metabolism Without Affecting CDG Serum Markers.Human mutation · 2025Review
- LMAN1 serves as a cargo receptor for thrombopoietin.JCI insight · 2024Article
- Article
- Mass production of iPSC-derived platelets toward the clinical application.Regenerative therapy · 2024Review
- Novel GNE missense variants impair de novo sialylation and cause defective angiogenesis in the developing brain in mice.Blood advances · 2024Article
- Analysis of the Healthy Platelet Proteome Identifies a New Form of Domain-Specific O-Fucosylation.Molecular & cellular proteomics : MCP · 2024Article
- Homeostatic Functions of Tissue-Resident Macrophages and Their Role in Tissue Maintenance.Results and problems in cell differentiation · 2024Review
- Review
- Specific O-glycans in the mechanosensory domain of glycoprotein Ibα are important for its stability and function.Haematologica · 2023Article
- Mucins Shed from the Laminated Layer in Cystic Echinococcosis Are Captured by Kupffer Cells via the Lectin Receptor Clec4F.Infection and immunity · 2023Article
- Article
- Immunology of a unique biological structure: the Echinococcus laminated layer.Protein & cell · 2023Article
- Inherited Thrombocytopenia Caused by Variants in Crucial Genes for Glycosylation.International journal of molecular sciences · 2023Review
- Commentary on "Desialylated Platelets Maintain Immune Quiescence through Regulating Kupffer Cells".Research (Washington, D.C.) · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 2 countries.
Yun LiJiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
Jianxin FuJiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
Yun LingJiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
Tadayuki YagoCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
J Michael McDanielCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Jianhua SongCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Xia BaiJiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
Yuji KondoCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Yannan QinCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Christopher HooverCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Samuel McGeeCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Bojing ShaoCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Zhenghui LiuCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Roberto SononComplex Carbohydrate Research Center, University of Georgia, Athens, GA 30602.
Parastoo AzadiComplex Carbohydrate Research Center, University of Georgia, Athens, GA 30602.
Jamey D MarthDepartment of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106.
Rodger P McEverCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Changgeng RuanJiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
Lijun XiaJiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China; lijun-xia@omrf.org.
Oklahoma Medical Research Foundation · USSoochow University · CNFirst Affiliated Hospital of Soochow University · CNUniversity of Georgia · USUniversity of California, Santa Barbara · USUniversity of Oklahoma Health Sciences Center · USXi'an Jiaotong University · CN
Funding
Protein Glycosylation in the Coagulopathy and Inflammation of SepsisP01HL131474 · NHLBI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ESKO, JEFFREY D · 2016 to 2025
$26.2MTR&D1: Stem Cell and Induced Pluripotent Stem Cell Resources (Pages 116-134)P41GM103490 · NIGMS · UNIVERSITY OF GEORGIA · PI PIERCE, J. MICHAEL · 2012 to 2018
$13.7MGLYCOSYLTRANSFERASE FUNCTION IN DEVELOPMENT AND DISEASER01DK048247 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMEY MARTH · 1994 to 2026
$9.4MPilot ProjectP30GM114731 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MCEVER, RODGER PAUL · 2016 to 2020
$6.5MGlycoprotein Remodeling in the Vasculopathy and Coagulopathy of SepsisR01HL125352 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MARTH, JAMEY, NIZET, VICTOR · 2014 to 2018
$3.6MPodoplanin-mediated platelet activation and vascular integrity in the developing brainR01HD083418 · NICHD · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI XIA, LIJUN · 2015 to 2019
$1.8MPlatelet CLEC-2 regulation of vascular integrity during inflammationR01HL128390 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MCEVER, RODGER PAUL, XIA, LIJUN · 2016 to 2019
$1.7MOrbitrap Fusion Tribrid Mass SpectrometerS10OD018530 · OD · UNIVERSITY OF GEORGIA · PI AZADI, PARASTOO · 2014 to 2014
$750kNHLBI NIH HHS P01 HL131474NHLBI NIH HHS R01 HL125352NHLBI NIH HHS R01 HL128390NICHD NIH HHS R01 HD083418NIDDK NIH HHS R01 DK048247NIGMS NIH HHS P30 GM114731NIGMS NIH HHS P41 GM103490NIH HHS S10 OD018530
Abstract
Most platelet membrane proteins are modified by mucin-type core 1-derived glycans (O-glycans). However, the biological importance of O-glycans in platelet clearance is unclear. Here, we generated mice with a hematopoietic cell-specific loss of O-glycans (HC
Indexed as
AnimalsAsialoglycoprotein ReceptorBlood PlateletsGalactosyltransferasesHepatocytesHomeostasisKupffer CellsLectins, C-TypeLiverMiceMice, Inbred C57BLMice, KnockoutN-Acetylneuraminic AcidPolysaccharidesThrombocytopeniaAsialoglycoprotein ReceptorC1galt1 protein, mouseCLEC4F protein, mouseGalactosyltransferasesLectins, C-TypeN-Acetylneuraminic AcidPolysaccharidesclearanceKupffer cellO-glycanplatelet
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.