Evidence map›Paper›PMID 28716903›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α

Vrajesh V Parekh, Sudheer K Pabbisetty, Lan Wu, Eric Sebzda, Jennifer Martinez, Jianhua Zhang, Luc Van Kaer

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 72 citations in OpenAlex.

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  19. The role of autophagy in viral infections.Journal of biomedical science · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Vrajesh V ParekhDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Sudheer K PabbisettyDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Lan WuDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Eric SebzdaDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Jennifer MartinezImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Jianhua ZhangDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.
Luc Van KaerDepartment of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232; luc.van.kaer@vanderbilt.edu.ORCID 0000-0001-5275-2309
Vanderbilt University · USNational Institute of Environmental Health Sciences · USUniversity of Alabama at Birmingham · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Characterization of the molecular mechanisms of LC3-associated phagocytosis and its role in disease pathogenesisZIAES103286 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MARTINEZ, JENNIFER · 2015 to 2021
$9.2M
Alpha-synuclein degradation mechanismsR01NS064090 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHANG, JIANHUA · 2010 to 2014
$1.6M
Glycolipid-Reactive NKT Cells, Obesity and Insulin ResistanceR01DK081536 · NIDDK · VANDERBILT UNIVERSITY · PI VAN KAER, LUC, WU, LAN · 2010 to 2013
$1.3M
iCD8alpha cells as novel innate-type lymphoid cells that mediate gut immunityR01DK104817 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VAN KAER, LUC · 2015 to 2018
$1.3M
LSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560k
NCI NIH HHS P30 CA068485NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK081536NIDDK NIH HHS R01 DK104817NIH HHS S10 OD021630NINDS NIH HHS R01 NS064090
6 · The paper itself

Abstract

The class III PI3K Vacuolar protein sorting 34 (Vps34) plays a role in both canonical and noncanonical autophagy, key processes that control the presentation of antigens by dendritic cells (DCs) to naive T lymphocytes. We generated DC-specific

Indexed as

AnimalsAntigen PresentationAutophagyAutophagy-Related ProteinsCD8 AntigensCD8-Positive T-LymphocytesCells, CulturedClass III Phosphatidylinositol 3-KinasesCross-PrimingCytokinesDendritic CellsEndocytosisHistocompatibility Antigens Class IMelanoma, ExperimentalMembrane ProteinsMiceAutophagy-Related ProteinsCD8alpha antigenCD8 AntigensClass III Phosphatidylinositol 3-KinasesCytokinesHistocompatibility Antigens Class IMembrane ProteinsTIM-4 protein, mouseantigen presentationcross-presentationdendritic cellsMHC class IVps34

Identifiers

PMID28716903
PMCPMC5547642
OpenAlexW2734984725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.