ArticleNeuroImage2017
Big GABA: Edited MR spectroscopy at 24 research sites.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 2 pooled it
13.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
112 citing papers in PubMed, 2 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review.Human brain mapping · 2021Pooled it
- Pooled it
- Dose-Dependent Effects of Catecholaminergic Modulation on Interference Control: Role of Baseline GABA and Glx in Cortico-Subcortical Networks.Human brain mapping · 2025Trial
- Neuroimaging Insights: Kava's (Nutrients · 2023Trial
- The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder.Journal of autism and developmental disorders · 2022Trial
- Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm.NeuroImage · 2021Trial
- GABA quantification in human anterior cingulate cortex.PloS one · 2021Trial
- Improving Fetal Single-Voxel Magnetic Resonance Spectroscopy With Spectral Registration.Magnetic resonance in medicine · 2026Article
- GABA+-Edited Magnetic Resonance Spectroscopy Deep Learning Quality Assessment Framework.Magnetic resonance in medicine · 2026Article
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Spectral Representation of Neurochemicals With Phase, Frequency Offset, and Lineshape Invariance: Application to JPRESS for In Vivo Concentration and TMagnetic resonance in medicine · 2026Article
- Anterior middle cingulate cortex gamma-aminobutyric acid level is elevated in children with both familial and prenatal alcohol exposure-associated attention deficit hyperactivity disorder.medRxiv : the preprint server for health sciences · 2026Article
- The association among glutamate, GABA, and anterior cingulate connectivity in schizophrenia spectrum disorders: Implications for symptom domains.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Identifying Out-of-Voxel Echoes in Edited MRS With Phase Cycle Inversion.Magnetic resonance in medicine · 2026Article
- A Longitudinal Assessment of Anterior Cingulate Cortex Gamma-aminobutyric Acid in Antipsychotic Medication-naïve First Episode Psychosis Patients.Schizophrenia bulletin · 2026Article
- Elevated neurotransmitter levels in people with HIV are associated with attention function.Neurobiology of disease · 2026Article
- Neurochemical changes in GABA+, Glx, and the excitatory/inhibitory ratio in the calcarine cortex with healthy aging.NeuroImage · 2025Article
- Disentangling metabolic and neurovascular timescales supporting cognitive processes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Relationships between GABA + and Glx concentrations with age and inhibition in healthy older adults.Brain structure & function · 2025Article
- MRS-BIDS, an extension to the Brain Imaging Data Structure for magnetic resonance spectroscopy.Scientific data · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
60 authors at 20 institutions in 9 countries.
Mark MikkelsenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Peter B BarkerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Pallab K BhattacharyyaImaging Institute, Cleveland Clinic Foundation, Cleveland, OH, USA; Radiology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Maiken K BrixDepartment of Radiology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Pieter F BuurSpinoza Centre for Neuroimaging, Amsterdam, The Netherlands.
Kim M CecilDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kimberly L ChanRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David Y-T ChenDepartment of Radiology, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan.
Alexander R CravenDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway; NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway.
Koen CuypersDepartment of Kinesiology, KU Leuven, Leuven, Belgium; REVAL Rehabilitation Research Center, Hasselt University, Diepenbeek, Belgium.
Michael DackoDepartment of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Niall W DuncanBrain and Consciousness Research Centre, Taipei Medical University, Taipei, Taiwan.
Ulrike DydakSchool of Health Sciences, Purdue University, West Lafayette, IN, USA.
David A EdmondsonSchool of Health Sciences, Purdue University, West Lafayette, IN, USA.
Gabriele EndeDepartment of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany.
Lars ErslandDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway; NORMENT - Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway; Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway.
Fei GaoShandong Medical Imaging Research Institute, Shandong University, Jinan, China.
Ian GreenhouseHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Ashley D HarrisDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Naying HeDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Stefanie HebaDepartment of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany.
Nigel HoggardAcademic Unit of Radiology, University of Sheffield, Sheffield, UK.
Tun-Wei HsuDepartment of Radiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Jacobus F A JansenDepartment of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands.
Alayar KangarluDepartment of Psychiatry, Columbia University, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
Thomas LangeDepartment of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
R Marc LebelGE Healthcare, Calgary, AB, Canada.
Yan LiDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chien-Yuan E LinGE Healthcare, Taipei, Taiwan.
Jy-Kang LiouDepartment of Radiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Jiing-Feng LirngDepartment of Radiology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Feng LiuNew York State Psychiatric Institute, New York, NY, USA.
Ruoyun MaSchool of Health Sciences, Purdue University, West Lafayette, IN, USA.
Celine MaesDepartment of Kinesiology, KU Leuven, Leuven, Belgium.
Marta Moreno-OrtegaDepartment of Psychiatry, Columbia University, New York, NY, USA.
Scott O MurrayDepartment of Psychology, University of Washington, Seattle, WA, USA.
Sean NoahHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Ralph NoeskeGE Healthcare, Berlin, Germany.
Michael D NoseworthyDepartment of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada.
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
James J PrisciandaroDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA.
Nicolaas A J PutsRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Timothy P L RobertsDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Markus SackDepartment of Neuroimaging, Central Institute of Mental Health, Mannheim, Germany.
Napapon SailasutaResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Muhammad G SalehRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Michael-Paul SchallmoDepartment of Psychology, University of Washington, Seattle, WA, USA.
Nicholas SimardSchool of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.
Stephan P SwinnenDepartment of Kinesiology, KU Leuven, Leuven, Belgium; Leuven Research Institute for Neuroscience & Disease (LIND), KU Leuven, Leuven, Belgium.
Martin TegenthoffDepartment of Neurology, BG University Hospital Bergmannsheil, Bochum, Germany.
Peter TruongResearch Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Guangbin WangShandong Medical Imaging Research Institute, Shandong University, Jinan, China.
Iain D WilkinsonAcademic Unit of Radiology, University of Sheffield, Sheffield, UK.
Hans-Jörg WittsackDepartment of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Hongmin XuDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fuhua YanDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chencheng ZhangDepartment of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Vadim ZipunnikovDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Helge J ZöllnerDepartment of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Electronic address: raee2@jhu.edu.
Heinrich Heine University Düsseldorf · DEVIB-KU Leuven Center for Brain & Disease Research · BEShanghai Jiao Tong University · CNJohns Hopkins University · USMcMaster University · CABG University Hospital Bergmannsheil Bochum · DEGeneral Electric (Canada) · CAHaukeland University Hospital · NOKennedy Krieger Institute · USKU Leuven · BENew York State Psychiatric InstitutePurdue University West Lafayette · USRuijin Hospital · CNUniversity of Bergen · NOUniversity of Toronto · CACentral Institute of Mental Health · DECincinnati Children's Hospital Medical Center · USCleveland Clinic Lerner College of Medicine · USColumbia University · USNational Yang Ming Chiao Tung University · TW
Funding
TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Lisa M McTeague · 1996 to 2026
$46.8MTR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1MThe Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI YUDKOFF, MARC · 2016 to 2020
$6.3MUniversal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4MSimultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8MImaging Framework for Testing GABAergic/glutamatergic Drugs in Bipolar AlcoholicsR01AA025365 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2017 to 2022
$2.7MNeuroimaging mechanisms of overlap between alcoholism and bipolar disorderK23AA020842 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2012 to 2016
$835kA Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum DisorderR00MH107719 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PUTS, NICOLAAS · 2018 to 2019
$492kGabapentin for Bipolar & Cannabis Use Disorders: Relation to Brain GABA/GlutamateR21DA043917 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PRISCIANDARO, JAMES JOSEPH · 2017 to 2018
$411kA Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum DisorderK99MH107719 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PUTS, NICOLAAS · 2016 to 2017
$165kDefining separate mechanisms of surround suppression in human visual cortexF32EY025121 · NEI · UNIVERSITY OF WASHINGTON · PI SCHALLMO, MICHAEL-PAUL · 2015 to 2017
$110kNEI NIH HHS F32 EY025121NIAAA NIH HHS K23 AA020842NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIMH NIH HHS K99 MH107719
Abstract
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid (GABA) in the human brain. Its increasing popularity has been aided by improvements in scanner hardware and acquisition methodology, as well as by broader access to pulse sequences that can selectively detect GABA, in particular J-difference spectral editing sequences. Nevertheless, implementations of GABA-edited MRS remain diverse across research sites, making comparisons between studies challenging. This large-scale multi-vendor, multi-site study seeks to better understand the factors that impact measurement outcomes of GABA-edited MRS. An international consortium of 24 research sites was formed. Data from 272 healthy adults were acquired on scanners from the three major MRI vendors and analyzed using the Gannet processing pipeline. MRS data were acquired in the medial parietal lobe with standard GABA+ and macromolecule- (MM-) suppressed GABA editing. The coefficient of variation across the entire cohort was 12% for GABA+ measurements and 28% for MM-suppressed GABA measurements. A multilevel analysis revealed that most of the variance (72%) in the GABA+ data was accounted for by differences between participants within-site, while site-level differences accounted for comparatively more variance (20%) than vendor-level differences (8%). For MM-suppressed GABA data, the variance was distributed equally between site- (50%) and participant-level (50%) differences. The findings show that GABA+ measurements exhibit strong agreement when implemented with a standard protocol. There is, however, increased variability for MM-suppressed GABA measurements that is attributed in part to differences in site-to-site data acquisition. This study's protocol establishes a framework for future methodological standardization of GABA-edited MRS, while the results provide valuable benchmarks for the MRS community.
Indexed as
AdultBrainDatasets as TopicFemalegamma-Aminobutyric AcidHumansMagnetic Resonance SpectroscopyMaleYoung Adultgamma-Aminobutyric AcidEditingGABAMEGA-PRESSMRSMulti-site study
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