Evidence map›Paper›PMID 28716620›Full record

ArticleJournal of pain and symptom management2017

Distinct Physical Function Profiles in Older Adults Receiving Cancer Chemotherapy.

Christine Miaskowski, Melisa L Wong, Bruce A Cooper, Judy Mastick, Steven M Paul, Katherine Possin, Michael Steinman, Janine Cataldo, Laura B Dunn, Christine Ritchie

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain and symptom management, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Characteristics associated with decrements in objective measures of physical function in older patients with cancer during chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  7. Article
  8. Article
  9. Co-occurrence of decrements in physical and cognitive function is common in older oncology patients receiving chemotherapy.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Christine MiaskowskiSchool of Nursing, University of California, San Francisco, California, USA. Electronic address: chris.miaskowski@ucsf.edu.
Melisa L WongSchool of Medicine, University of California, San Francisco, California, USA.
Bruce A CooperSchool of Nursing, University of California, San Francisco, California, USA.
Judy MastickSchool of Nursing, University of California, San Francisco, California, USA.
Steven M PaulSchool of Nursing, University of California, San Francisco, California, USA.
Katherine PossinSchool of Medicine, University of California, San Francisco, California, USA.
Michael SteinmanSchool of Medicine, University of California, San Francisco, California, USA.
Janine CataldoSchool of Nursing, University of California, San Francisco, California, USA.
Laura B DunnSchool of Medicine, Stanford University, Palo Alto, California, USA.
Christine RitchieSchool of Medicine, University of California, San Francisco, California, USA.
University of California, San Francisco · USStanford University · US

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2013 to 2026
$19.9M
Institutional Career Development Core SupplementKL2TR001870 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SARKAR, URMIMALA · 2016 to 2025
$19.7M
RESEARCH TRAINING IN GERIATRIC MEDICINET32AG000212 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 1991 to 2026
$7.7M
Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
Advancing the Science of Symptom Management in Oncology PatientsK05CA168960 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MIASKOWSKI, CHRISTINE A. · 2013 to 2017
$453k
NCATS NIH HHS KL2 TR001870NCI NIH HHS K05 CA168960NCI NIH HHS R01 CA134900NIA NIH HHS P30 AG044281NIA NIH HHS T32 AG000212
6 · The paper itself

Abstract

contextAlthough physical function is an important patient outcome, little is known about changes in physical function in older adults receiving chemotherapy (CTX).

objectivesIdentify subgroups of older patients based on changes in their level of physical function; determine which demographic and clinical characteristics were associated with subgroup membership; and determine if these subgroups differed on quality-of-life (QOL) outcomes.

methodsLatent profile analysis was used to identify groups of older oncology patients (n = 363) with distinct physical function profiles. Patients were assessed six times over two cycles of CTX using the Physical Component Summary score from the Short Form 12. Differences, among the groups, in demographic and clinical characteristics and QOL outcomes were evaluated using parametric and nonparametric tests.

resultsThree groups of older oncology patients with distinct functional profiles were identified: Well Below (20.4%), Below (43.8%), and Above (35.8%) normative Physical Component Summary scores. Characteristics associated with membership in the Well Below class included the following: lower annual income, a higher level of comorbidity, being diagnosed with depression and back pain, and lack of regular exercise. Compared with the Above class, patients in the other two classes had significantly poorer QOL outcomes.

conclusionAlmost 65% of older oncology patients reported significant decrements in physical function that persisted over two cycles of CTX. Clinicians can assess for those characteristics associated with poorer functional status to identify high-risk patients and initiate appropriate interventions.

Indexed as

AgedAntineoplastic AgentsBack PainCohort StudiesComorbidityDepressionExerciseFemaleHumansMaleNeoplasmsQuality of LifeSocioeconomic FactorsAntineoplastic Agentschemotherapycomorbiditylatent class analysisolder adultsPhysical function

Identifiers

PMID28716620
PMCPMC5610084
OpenAlexW2734753825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.