Evidence map›Paper›PMID 28716389›Full record

ReviewDevelopmental cognitive neuroscience2018

Biomedical ethics and clinical oversight in multisite observational neuroimaging studies with children and adolescents: The ABCD experience.

Duncan B Clark, Celia B Fisher, Susan Bookheimer, Sandra A Brown, John H Evans, Christian Hopfer, James Hudziak, Ivan Montoya, Margaret Murray, Adolf Pfefferbaum and 1 more

Open access · goldAbstract readMulticenter StudyReview
In one paragraph

Review in Developmental cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 135 citations in OpenAlex.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 1 country.

Duncan B Clark3811 O'Hara Street, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15215, United States. Electronic address: clarkdb@upmc.edu.
Celia B Fisher441 East Fordham Road, Dealy Hall, Fordham University, Bronx, NY 10458, United States. Electronic address: fisher@fordham.edu.
Susan BookheimerDepartment of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA 90095, United States. Electronic address: sbook@ucla.edu.
Sandra A BrownDepartment of Psychology and Psychiatry, UC San Diego, 9500 Gilman Drive (MC 0043), La Jolla, CA 92093, United States. Electronic address: sandrabrown@ucsd.edu.
John H EvansDepartment of Sociology, UC San Diego, 9500 Gilman Drive (0533), La Jolla, CA 92093, United States. Electronic address: jhevans@ucsd.edu.
Christian HopferDepartment of Psychiatry, University of Colorado, Denver School of Medicine, 12469 E 17th Place (Bldg 400), Mail Stop F478, Aurora CO 80045, United States. Electronic address: christian.hopfer@ucdenver.edu.
James HudziakUHC Campus, St. Joe's Room 3213, Box 364SJ 3, 1 South Prospect, Burlington, VT 05401, United States. Electronic address: james.hudziak@med.uvm.edu.
Ivan MontoyaOffice of the DTMC Director, National Institute on Drug Abuse, 6001 Executive Boulevard, Bethesda, MD, United States. Electronic address: imontoya@mail.nih.gov.
Margaret MurrayOffice of the Director, National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Rockville, MD, United States. Electronic address: pmurray@willco.niaaa.nih.gov.
Adolf PfefferbaumNeuroscience Program, SRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, United States. Electronic address: dolf@synapse.sri.com.
Deborah Yurgelun-ToddDepartment of Psychiatry, University of Utah School of Medicine, 501 Chipeta Way, Salt Lake City, UT 84108, United States. Electronic address: deborah.yurgelun-todd@hsc.utah.edu.
University of California, San Diego · USFordham University · USNational Institute on Drug Abuse · USNeurobehavioral Systems · USOffice of the Director · USSRI International · USSt. Joseph Hospital · USUniversity of Colorado Denver · USUniversity of Pittsburgh · USUniversity of Utah · US

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7M
ABCD-USA Consortium:Research ProjectU01DA041028 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN B. CLARK, BEATRIZ LUNA · 2015 to 2026
$13.9M
21/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT WUSTLU01DA051038 · NIDA · WASHINGTON UNIVERSITY · PI Deanna Barch, ANDREW C. HEATH · 2020 to 2026
$13.7M
ABCD-USA Consortium: Research ProjectU01DA041022 · NIDA · SRI INTERNATIONAL · PI Fiona C Baker, Eva M Muller-Oehring · 2015 to 2026
$13.4M
NICHD NIH HHS U54 HD087101NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147
6 · The paper itself

Abstract

Observational neuroimaging studies with children and adolescents may identify neurological anomalies and other clinically relevant findings. Planning for the management of this information involves ethical considerations that may influence informed consent, confidentiality, and communication with participants about assessment results. Biomedical ethics principles include respect for autonomy, beneficence, non-maleficence, and justice. Each project presents unique challenges. The Adolescent Brain and Cognitive Development study (ABCD) collaborators have systematically developed recommendations with written guidelines for identifying and responding to potential risks that adhere to biomedical ethics principles. To illustrate, we will review the ABCD approach to three areas: (1) hazardous substance use; (2) neurological anomalies; and (3) imminent potential for self-harm or harm to others. Each ABCD site is responsible for implementing procedures consistent with these guidelines in accordance with their Institutional Review Board approved protocols, state regulations, and local resources. To assure that each site has related plans and resources in place, site emergency procedures manuals have been developed, documented and reviewed for adherence to ABCD guidelines. This article will describe the principles and process used to develop these ABCD bioethics and medical oversight guidelines, the concerns and options considered, and the resulting approaches advised to sites.

Indexed as

AdolescentAdolescent DevelopmentBioethicsBrainChildCognitionFemaleHumansMagnetic Resonance ImagingMaleNeuroimagingAdolescenceClinical oversightEthicsMagnetic resonance imagingSubstance use

Identifiers

PMID28716389
PMCPMC5745294
OpenAlexW2731355685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.