Evidence map›Paper›PMID 28716328›Full record

ReviewThe Urologic clinics of North America2017

New Frontiers of Basic Science Research in Neurogenic Lower Urinary Tract Dysfunction.

Minoru Miyazato, Katsumi Kadekawa, Takeya Kitta, Naoki Wada, Nobutaka Shimizu, William C de Groat, Lori A Birder, Anthony J Kanai, Seiichi Saito, Naoki Yoshimura

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Urologic clinics of North America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Minoru MiyazatoDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan; Department of Urology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
Katsumi KadekawaDepartment of Urology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
Takeya KittaDepartment of Urology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
Naoki WadaDepartment of Urology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
Nobutaka ShimizuDepartment of Urology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA.
William C de GroatDepartment of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15216, USA.
Lori A BirderDepartment of Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15216, USA.
Anthony J KanaiDepartment of Medicine, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15216, USA.
Seiichi SaitoDepartment of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan.
Naoki YoshimuraDepartment of Urology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15216, USA. Electronic address: nyos@pitt.edu.

Funding

Urothelium in Detrusor OveractivityP01DK093424 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEGROAT, WILLIAM C · 2013 to 2017
$7.9M
PDE5 Inhibition of Afferents and Interstitial Cells in Overactive Mouse BladdersR01DK098361 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRDER, LORI A, KANAI, ANTHONY JOHN · 2014 to 2024
$5.7M
Pharmacology of Intravesical Antisense Based Therapy for Over Active BladderR01DK088836 · NIDDK · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI CHANCELLOR, MICHAEL B, TYAGI, PRADEEP · 2011 to 2014
$1.3M
Afferent modulation in bladder dysfunctionR01DK068557 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YOSHIMURA, NAOKI · 2004 to 2007
$1.1M
NIDDK NIH HHS P01 DK093424NIDDK NIH HHS R01 DK068557NIDDK NIH HHS R01 DK088836NIDDK NIH HHS R01 DK098361
6 · The paper itself

Abstract

The lower urinary tract's main functions are storage and elimination. The micturition reflex pathway is modulated by the spinobulbospinal reflex pathway as well as higher brain centers involved in the voluntary micturition control. Micturition is sensitive to numerous injuries, resulting in various types of dysfunction. Animal studies indicate that lower urinary tract dysfunction partly depends on plasticity of the neural pathways. Reflex plasticity is associated with changes in ion channels, receptors, and numerous mediators. Animal models may aid in understanding the mechanisms leading to pathologic conditions and the plasticity in reflex pathways to the lower urinary tract after neurogenic lesions.

Indexed as

Biomedical ResearchLower Urinary Tract SymptomsAnimalsCerebral InfarctionDisease Models, AnimalHumansNervous SystemParkinson DiseaseSpinal Cord InjuriesUrethraUrinary BladderAfferentsAnimal modelCentral nervous systemLower urinary tract

Identifiers

PMID28716328
PMCPMC5647782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.