Evidence map›Paper›PMID 28716122›Full record

ArticleJournal of nanobiotechnology2017

Systematic evaluation of oligodeoxynucleotide binding and hybridization to modified multi-walled carbon nanotubes.

Anika Kaufmann, Silke Hampel, Christiane Rieger, David Kunhardt, Darja Schendel, Susanne Füssel, Bernd Schwenzer, Kati Erdmann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anika KaufmannChair of Biochemistry, Department of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069, Dresden, Germany.
Silke HampelLeibniz Institute for Solid State and Materials Research Dresden, Helmholtzstraße 20, 01069, Dresden, Germany.
Christiane RiegerDepartment of Urology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
David KunhardtLeibniz Institute for Solid State and Materials Research Dresden, Helmholtzstraße 20, 01069, Dresden, Germany.
Darja SchendelDepartment of Urology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
Susanne FüsselDepartment of Urology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. susanne.fuessel@mailbox.tu-dresden.de.
Bernd SchwenzerChair of Biochemistry, Department of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069, Dresden, Germany.
Kati ErdmannDepartment of Urology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
TU Dresden · DELeibniz Institute for Solid State and Materials Research · DEUniversity Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn addition to conventional chemotherapeutics, nucleic acid-based therapeutics like antisense oligodeoxynucleotides (AS-ODN) represent a novel approach for the treatment of bladder cancer (BCa). An efficient delivery of AS-ODN to the urothelium and then into cancer cells might be achieved by the local application of multi-walled carbon nanotubes (MWCNT). In the present study, pristine MWCNT and MWCNT functionalized with hydrophilic moieties were synthesized and then investigated regarding their physicochemical characteristics, dispersibility, biocompatibility, cellular uptake and mucoadhesive properties. Finally, their binding capacity for AS-ODN via hybridization to carrier strand oligodeoxynucleotides (CS-ODN), which were either non-covalently adsorbed or covalently bound to the different MWCNT types, was evaluated.

resultsPristine MWCNT were successfully functionalized with hydrophilic moieties (MWCNT-OH, -COOH, -NH

conclusionsIn conclusion, functionalized MWCNT might be used as nanotransporters in antisense therapy for the local treatment of BCa.

Indexed as

AdsorptionAnimalsCell AdhesionCell LineCell SurvivalDrug CarriersDrug LiberationHumansMiceNanotubes, CarbonNucleic Acid HybridizationOligodeoxyribonucleotidesOligonucleotides, AntisenseSurface PropertiesUrinary BladderUrotheliumDrug CarriersNanotubes, CarbonOligodeoxyribonucleotidesOligonucleotides, AntisenseAntisense oligodeoxynucleotidesBiocompatibilityBladder cancerCarbon nanotubesCarrier strandFunctionalizationHybridizationMucoadhesionUrothelium

Identifiers

PMID28716122
PMCPMC5513106
OpenAlexW2735858281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.