Evidence map›Paper›PMID 28716039›Full record

SynthesisJournal of cardiothoracic surgery2017

Extra-corporeal membrane oxygenation for refractory cardiogenic shock after adult cardiac surgery: a systematic review and meta-analysis.

Maziar Khorsandi, Scott Dougherty, Omar Bouamra, Vasudev Pai, Philip Curry, Steven Tsui, Stephen Clark, Stephen Westaby, Nawwar Al-Attar, Vipin Zamvar

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of cardiothoracic surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 4 pooled it
22.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 193 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  5. Article
  6. Observational
  7. Review
  8. Current insights on temporary mechanical circulatory support in adults with post-cardiotomy cardiogenic shock.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  9. 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.Interdisciplinary cardiovascular and thoracic surgery · 2025
    Article
  10. 2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025
    Article
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
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  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Maziar KhorsandiDepartment of Cardiac Surgery and Transplantation, Golden Jubilee National Hospital, Glasgow, UK. maziarkhorsandi@doctors.org.uk.
Scott DoughertyDepartment of Cardiology, Ninewells hospital, Dundee, UK.
Omar BouamraMedical Statistics, Trauma, Audit & Research Network, University of Manchester, Salford Royal NHS foundation trust, Manchester, UK.
Vasudev PaiDepartment of Cardiovascular and Thoracic Surgery, Kasturba Medical College, Manipal University, Manipal, India.
Philip CurryDepartment of Cardiac Surgery and Transplantation, Golden Jubilee National Hospital, Glasgow, UK.
Steven TsuiDepartment of Cardiac Surgery and Transplantation, Papworth hospital, Cambridge, UK.
Stephen ClarkDepartment of Cardiac surgery and Transplantation, Freeman hospital, Newcastle, UK.
Stephen WestabyDepartment of Cardiac Surgery, Oxford Heart Center, John Radcliffe Hospital, Oxford, UK.
Nawwar Al-AttarDepartment of Cardiac Surgery and Transplantation, Golden Jubilee National Hospital, Glasgow, UK.
Vipin ZamvarDepartment of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK.
Golden Jubilee National Hospital · GBEdinburgh Royal Infirmary · GBFreeman Hospital · GBJohn Radcliffe Hospital · GBKasturba Medical College, Manipal · INNinewells Hospital · GBPapworth Hospital · GBSalford Royal NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostcardiotomy cardiogenic shock (PCCS) refractory to inotropic support and intra-aortic balloon pump (IABP) occurs rarely but is almost universally fatal without mechanical circulatory support. In this systematic review and meta-analysis we looked at the evidence behind the use of veno-arterial extra-corporeal membrane oxygenation (VA ECMO) in refractory PCCS from a patient survival rate and determinants of outcome viewpoint.

methodsA systematic review was performed in January 2017 using PubMed (with no defined time period) using the keywords "postcardiotomy", "cardiogenic shock", "extracorporeal membrane oxygenation" and "cardiac surgery". We excluded papers pertaining to ECMO following paediatric cardiac surgery, medical causes of cardiogenic shock, as well as case reports, review articles, expert opinions, and letters to the editor. Once the studies were collated, a meta-analysis was performed on the proportion of survivors in those papers that met the inclusion criteria. Meta-regression was performed for the most commonly reported adverse prognostic indicators (API).

resultsWe identified 24 studies and a cumulative pool of 1926 patients from 1992 to 2016. We tabulated the demographic data, including the strengths and weaknesses for each of the studies, outcomes of VA ECMO for refractory PCCS, complications, and APIs. All the studies were retrospective cohort studies. Meta-analysis of the moderately heterogeneous data (95% CI 0.29 to 0.34, p < 0.01, I

conclusionHaemodynamic support with VA ECMO provides a survival benefit with reasonable intermediate and long-term outcomes. Many studies had reported advanced age, renal failure and prolonged VA ECMO support as the most likely APIs for VA ECMO in PCCS. EuroSCORE can be utilized to anticipate the need for prophylactic perioperative VA ECMO in the high-risk category. APIs can be used to aid decision-making regarding both the institution and weaning of ECMO for refractory PCCS.

Indexed as

AdultCardiac Surgical ProceduresExtracorporeal Membrane OxygenationHumansPostoperative ComplicationsShock, CardiogenicCardiogenic shockExtra-corporeal membrane oxygenationPostcardiotomy

Identifiers

PMID28716039
PMCPMC5512816
OpenAlexW2734344826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.