ArticleJournal of exercise nutrition & biochemistry2017
Effects of swimming exercise on high-fat diet-induced low bone mineral density and trabecular bone microstructure in rats.
Article in Journal of exercise nutrition & biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of aerobic treadmill exercise on the bone turnover in obese male mice.Frontiers in cell and developmental biology · 2025Article
- Effects of Different Types of Mechanical Loading on Trabecular Bone Microarchitecture in Rats.Journal of bone metabolism · 2021Article
- Swimming Training Does Not Affect the Recovery of Femoral Midshaft Structural and Mechanical Properties in Growing Diabetic Rats Treated with Insulin.Life (Basel, Switzerland) · 2021Article
- Article
- High Impact Exercise Improves Bone Microstructure and Strength in Growing Rats.Scientific reports · 2019Article
- Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice.Bone · 2019Article
- Swimming training potentiates the recovery of femoral neck strength in young diabetic rats under insulin therapy.Clinics (Sao Paulo, Brazil) · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to investigate the effect of swimming exercise on high-fat diet-induced low bone mineral density (BMD) and trabecular bone microstructure in rats.
methodsEight-week-old male Sprague- Dawley (SD) rats were divided into a normal diet group (n = 9) and a high-fat diet group (n = 15). Three rats in each group were sacrificed after 8 weeks of high-fat diet to evaluate the association between high-fat diet and bone health. The other 18 rats were reassigned to 3 groups (normal diet control, NC; high-fat diet control, HC; high-fat diet + Exercise, HEx) for up to another 8 weeks. Rats in the exercise group were trained for a swimming exercise program (1 h/day, 5 times/ week for 8 weeks). All rats were sacrificed 24 h after the last bout of exercise to analyze the BMD and trabecular bone microstructure in the femur and tibia, using micro-computed tomography.
resultsFirst, the effect of high-fat diet on bone health was examined. It was observed that BMD, percent bone volume (BV/TV), and trabecular number (Tb.N) of the femur and tibia were lower in rats in the high-fat diet group than in those in the normal diet group (p < .05). In addition, BMD, BV/TV, and Tb.N of the femur and tibia were significantly increased in rats that underwent the 8-week swimming exercise program, compared to the corresponding values in rats in the HC group (p < .05).
conclusionThese results indicate that high-fat diets negatively affect bone health; however, these negative effects can be improved by exercises such as swimming.
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