ArticleDrug and alcohol dependence2017
Gender differences in the real-world effectiveness of smoking cessation medications: Findings from the 2010-2011 Tobacco Use Supplement to the Current Population Survey.
Article in Drug and alcohol dependence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex- and Gender-Based Analysis in Cannabis Treatment Outcomes: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Urge Coping Mediates the Relationship Between Physical Activity and Smoking Outcomes in a Sample of Premenopausal Women Intending to Quit Smoking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Trial
- Feasibility and acceptability of testing a menstrual-cycle timed smoking cessation intervention for women of reproductive age (Project Phase): Results of a pilot randomized control trial.Addictive behaviors · 2022Trial
- Change in smoking cessation stage over 1 year in patients with schizophrenia: a follow up study in Japan.BMC psychiatry · 2019Trial
- Exogenous progesterone for smoking cessation in men and women: a pilot double-blind, placebo-controlled randomized clinical trial.Addiction (Abingdon, England) · 2019Trial
- Socioeconomic characteristics, tobacco use, and service utilization by county poverty status among Oklahoma tobacco helpline registrants: A crossTobacco prevention & cessation · 2026Article
- Is It Time to Update Clinical Care Guidelines to Address Sex and Gender Differences in Smoking Cessation Medication Efficacy?Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Review of Challenges in Performing Real-World Evidence Studies for Nonprescription Products.Pragmatic and observational research · 2025Review
- Gender, smoking, and tobacco cessation with pharmacological treatment in a cluster randomized clinical trial.Tobacco induced diseases · 2024Article
- A Review of Smoking Cessation Interventions: Efficacy, Strategies for Implementation, and Future Directions.Cureus · 2024Review
- Sex effects in predictors of smoking abstinence and neuropsychiatric adverse events in the EAGLES trial.Drug and alcohol dependence reports · 2023Article
- Consideration of sex and gender differences in addiction medication response.Biology of sex differences · 2022Review
- Biological determinants impact the neurovascular toxicity of nicotine and tobacco smoke: A pharmacokinetic and pharmacodynamics perspective.Neurotoxicology · 2022Review
- Affect and subjective cognitive functioning by depression symptom levels during naturalistic cigarette smoking in premenopausal females who smoke daily.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Article
- Gender Differences in Reasons for Using Electronic Cigarettes and Product Characteristics: Findings From the 2018 ITC Four Country Smoking and Vaping Survey.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Article
- Influence of the natural hormonal milieu on brain and behavior in women who smoke cigarettes: Rationale and methodology.Contemporary clinical trials communications · 2021Article
- Pharmacological interventions to address cigarette smoking in people with schizophrenia spectrum disorders.The lancet. Psychiatry · 2020Article
- Sex differences in the appeal of flavored e-cigarettes among young adult e-cigarette users.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Tobacco smoking and associated factors in human immunodeficiency virus-infected adults attending human immunodeficiency virus clinics in the Western Cape province, South Africa.Southern African journal of HIV medicine · 2020Article
- Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction.Current opinion in behavioral sciences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundMeta-analyses of clinical trial data have identified clinically relevant gender differences in the efficacy of smoking cessation pharmacotherapy. It is unclear whether these findings are generalizable to smokers quitting in real-world contexts.
methodsUsing Tobacco Use Supplement to the Current Population Survey (TUS-CPS) 2010-2011 cross-sectional data, we generated propensity score matched samples of smokers who quit either unassisted by medication, using only varenicline, or using only transdermal nicotine patch (TNP). We used generalized estimating equations to estimate gender differences in the comparative effectiveness of these cessation options for achieving 30-days of abstinence, adjusting for potential confounders.
resultsWhen stratified by gender, TNP was significantly more effective than unassisted quit attempts for men (OR=1.37; 95%CI=1.02,1.83; p=0.03), but not for women (OR=0.96; 95%CI=0.71,1.31; p=0.82). Varenicline was significantly more effective than unassisted quit attempts for women (OR=1.63; 95%CI=1.16, 2.31; p=0.005), but not men (OR=1.35; 95%CI=0.94,1.96; p=0.11). Varenicline was also more effective than TNP for women (OR=1.51; 95%CI=0.12,2.05; p=0.007) but not men (OR=0.92; 95%CI=0.65,1.31; p=0.64). A significant gender by medication interaction was found only for the comparison of varenicline to TNP (OR=1.64; 95%CI=1.04,2.61; p=0.04).
conclusionsFindings for varenicline vs. TNP were consistent with clinical trial data, showing greater differences in effectiveness for women compared to men. Results lend support to the generalizability of clinical trial findings, highlighting the importance of considering gender when offering treatment for smoking cessation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.