ArticlePloS one2017
Serum variations of anti-mullerian hormone and total testosterone with aging in healthy adult Iranian men: A population-based study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Anti-Müllerian Hormone as a Marker for Castration Status and Fertility in Bulls and Oxen.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Perspectives on biomarkers of reproductive aging for fertility and beyond.Nature aging · 2024Review
- Key predictors of fertility: Exploring the role of Vitamin-D.Pakistan journal of medical sciences · 2024Article
- Anti-Müllerian hormone as a diagnostic marker for testicular degeneration in dogs: insights from cryptorchid models.Frontiers in veterinary science · 2024Article
- Biomarkers of aging.Science China. Life sciences · 2023Review
- Anti-Müllerian hormone concentration is associated with central adiposity and reproductive hormones in expectant fathers.Clinical endocrinology · 2022Article
- Occupational Health Aspects with Special Focus on Physiological Differences between Office and Metalworkers.Antioxidants (Basel, Switzerland) · 2022Article
- Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update.Innovation (Cambridge (Mass.)) · 2021Review
- Anti-Müllerian hormone levels and risk of type 2 diabetes in women.Diabetologia · 2021Article
- Immunohistochemical characterization of the anti-Müllerian hormone receptor type 2 (AMHR-2) in human testes.Endocrine · 2020Article
- Premature ovarian aging inOncotarget · 2018Article
- Associations between Urinary Phthalate Metabolites and Serum Anti-Müller Hormone Levels in U.S. Men Based on National Health and Nutrition Examination Survey 2003-2004.International journal of environmental research and public health · 2017Article
- Abnormalities of Endocrine Function Tests in COVID-19-Recovered Individuals.Indian journal of endocrinology and metabolismArticle
- Regulation of anti-Müllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility.Asian journal of andrologyReview
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Authors and funding
5 authors.
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Abstract
backgroundLiterature proves anti-mullerian hormone (AMH) and total testosterone (TT) as two important reproductive hormones in male development, however evidence regarding age variations of these hormones is lacking.
aimsTo estimate the normal serum AMH values and to assess the age-specific TT levels in men aged 30-70, we conducted the present population-based study.
methodsA total of 831 healthy eligible men, aged 30-70 years, were recruited from Tehran Lipid and Glucose study cohort. Centiles for AMH were estimated according to the exponential normal 3-parameter model. The parametric method of Royston available in general software was applied for the first time to estimate the age-specific AMH and TT percentiles of 5th, 10th, 25th, 50th, 75th, 90th and 95th.
resultsMean AMH level was 6.93, ranging from 0.1 to 40.1 ng/ml. Serum AMH concentrations followed a steady reduction with increasing age. Mean TT level was 4.8, ranging from 0.44 to 11.4 ng/ml. DISCUSSION: A measurable serum concentrations of AMH in healthy males throughout lifespan with variations, based on age, confirming a slight age-related AMH decline. Fractional polynomial (FP) regression models revealed that the mean and standard deviation (SD) of the TT were not associated with age, so the percentiles estimated were not age-specific.
conclusionWe presented a nomogram of age-specific AMH values in a healthy cohort of Iranian men. This finding might have clinical importance in dealing hormonal disorders in men.
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