ArticlePloS one2017
Characterization of the maize lipoxygenase gene family in relation to aflatoxin accumulation resistance.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 62 citations in OpenAlex.
- Overexpression of the maize 9-lipoxygenase gene LOX4 confers resistance to Fusarium verticillioides via the oxylipin- and jasmonic acid-mediated pathways.Journal of experimental botany · 2026Article
- CRISPR/Cas9-mediated editing of barley lipoxygenase genes promotes grain fatty acid accumulation and storability.GM crops & food · 2025Article
- Article
- Plant oxylipins: adaptation to environmental stresses and impact on mycotoxin contamination.Frontiers in plant science · 2025Review
- Organizing the Chaos: Novel Insights into the Regulation of Z-3-Hexenal Production in Damaged Maize Leaves.Plants (Basel, Switzerland) · 2024Article
- Low expression of lipoxygenase 3 (LOX3) enhances the retention of kernel tocopherols in maize during storage.Molecular biology reports · 2023Article
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- Article
- Quorum Sensing-Mediated Lipid Oxidation Further Regulating the Environmental Adaptability ofMetabolites · 2023Article
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- Oxylipin biosynthetic gene families of Cannabis sativa.PloS one · 2023Article
- Identification and characterization of lipoxygenase (LOX) genes involved in abiotic stresses in yellow horn.PloS one · 2023Article
- Revealing Differential Expression of Phytohormones in Sorghum in Response to Aphid Attack Using the Metabolomics Approach.International journal of molecular sciences · 2022Article
- Comparative Analysis of Multiple GWAS Results Identifies Metabolic Pathways Associated with Resistance toToxins · 2022Article
- Functional Study of Lipoxygenase-Mediated Resistance againstInternational journal of molecular sciences · 2022Article
- Co-Transcriptomic Analysis of the Maize-Western Corn Rootworm Interaction.Plants (Basel, Switzerland) · 2022Article
- Identification and Characterization of Jasmonic Acid Biosynthetic Genes inInternational journal of molecular sciences · 2022Article
- Identification of the LOX Gene Family in Peanut and Functional Characterization ofFrontiers in plant science · 2022Article
- The Responses of the Lipoxygenase Gene Family to Salt and Drought Stress in Foxtail Millet (Life (Basel, Switzerland) · 2021Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maize (Zea mays L.) is a globally important staple food crop prone to contamination by aflatoxin, a carcinogenic secondary metabolite produced by the fungus Aspergillus flavus. An efficient approach to reduce accumulation of aflatoxin is the development of germplasm resistant to colonization and toxin production by A. flavus. Lipoxygenases (LOXs) are a group of non-heme iron containing dioxygenase enzymes that catalyze oxygenation of polyunsaturated fatty acids (PUFAs). LOX derived oxylipins play critical roles in plant defense against pathogens including A. flavus. The objectives of this study were to summarize sequence diversity and expression patterns for all LOX genes in the maize genome, and map their effect on aflatoxin accumulation via linkage and association mapping. In total, 13 LOX genes were identified, characterized, and mapped. The sequence of one gene, ZmLOX10, is reported from 5 inbred lines. Genes ZmLOX1/2, 5, 8, 9, 10 and 12 (GRMZM2G156861, or V4 numbers ZM00001D042541 and Zm00001D042540, GRMZM2G102760, GRMZM2G104843, GRMZM2G017616, GRMZM2G015419, and GRMZM2G106748, respectively) fell under previously published QTL in one or more mapping populations and are linked to a measurable reduction of aflatoxin in maize grains. Association mapping results found 28 of the 726 SNPs tested were associated with reduced aflatoxin levels at p ≤ 9.71 x 10-4 according to association statistics. These fell within or near nine of the ZmLOX genes. This work confirms the importance of some lipoxygenases for resistance to aflatoxin accumulation and may be used to direct future genetic selection in maize.
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