ArticlePLoS neglected tropical diseases2017
Zika virus alters the microRNA expression profile and elicits an RNAi response in Aedes aegypti mosquitoes.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- microRNA profiles and functions in mosquitoes.PLoS neglected tropical diseases · 2018Pooled it
- Temporal and spatial profiling of Aedes albopictus immune responses to chikungunya virus infection.PLoS neglected tropical diseases · 2025Article
- Zika virus modulates arthropod histone methylation for its survival in mosquito cells.PloS one · 2025Article
- Acute bee paralysis virus regulation of microRNA expression dynamics in the insect host (Frontiers in cellular and infection microbiology · 2025Article
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- Analysis ofbioRxiv : the preprint server for biology · 2024Article
- Response of the mosquito immune system and symbiotic bacteria to pathogen infection.Parasites & vectors · 2024Review
- Analysis ofFrontiers in cellular and infection microbiology · 2024Article
- microRNA Expression Dynamics inInsects · 2023Article
- Identification of MicroRNAs in the West Nile Virus Vector Culex tarsalis (Diptera: Culicidae).Journal of medical entomology · 2023Article
- Review
- Assessment of the Risk of Exotic Zika Virus Strain Transmission byTropical medicine and infectious disease · 2023Article
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- Insect-Specific Chimeric Viruses Potentiated Antiviral Responses and Inhibited Pathogenic Alphavirus Growth in Mosquito Cells.Microbiology spectrum · 2023Article
- Intrinsic factors driving mosquito vector competence and viral evolution: a review.Frontiers in cellular and infection microbiology · 2023Review
- The Involvement of Atlastin in Dengue Virus andMicrobiology spectrum · 2022Article
- MicroRNAs and other small RNAs in Aedes aegypti saliva and salivary glands following chikungunya virus infection.Scientific reports · 2022Article
- Transcriptomic and small RNA response to Mayaro virus infection in Anopheles stephensi mosquitoes.PLoS neglected tropical diseases · 2022Article
- Identification of microRNAs in the Lyme Disease VectorInternational journal of molecular sciences · 2022Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Zika virus (ZIKV), a flavivirus transmitted primarily by Aedes aegypti, has recently spread globally in an unprecedented fashion, yet we have a poor understanding of host-microbe interactions in this system. To gain insights into the interplay between ZIKV and the mosquito, we sequenced the small RNA profiles in ZIKV-infected and non-infected Ae. aegypti mosquitoes at 2, 7 and 14 days post-infection. ZIKA induced an RNAi response in the mosquito with virus-derived short interfering RNAs and PIWI-interacting RNAs dramatically increased in abundance post-infection. Further, we found 17 host microRNAs (miRNAs) that were modulated by ZIKV infection at all time points. Strikingly, many of these regulated miRNAs have been reported to have their expression altered by dengue and West Nile viruses, while the response was divergent from that induced by the alphavirus Chikungunya virus in mosquitoes. This suggests that conserved miRNA responses occur within mosquitoes in response to flavivirus infection. This study expands our understanding of ZIKV-vector interactions and provides potential avenues to be further investigated to target ZIKV in the mosquito host.
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