ArticlePain2017
Interacting influences of gender and chronic pain status on parasympathetically mediated heart rate variability in adolescents and young adults.
Article in Pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Clinical and translational gastroenterology · 2020Pooled it
- Familial Autonomic Ganglionopathy Caused by RareNeurology · 2021Trial
- Trial
- Heart rate control by listening to light.Nature communications · 2026Article
- Association Between Chronic Pain and Risk of Glaucoma: A Prospective Cohort Study.Translational vision science & technology · 2025Article
- Vagally Mediated Heart Rate Variability and Attachment-Related Avoidance in Pediatric Migraine: A Mediated Pathway to Somatic Symptoms Severity.Children (Basel, Switzerland) · 2025Article
- Development and Validation of a Multimodal Wearable Belt for Abdominal Biosignal Monitoring with Application to Irritable Bowel Syndrome.Micromachines · 2025Article
- Roles of Heart Rate Variability in Assessing Autonomic Nervous System in Functional Gastrointestinal Disorders: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Emotional Self-Regulation in Primary Education: A Heart Rate-Variability Biofeedback Intervention Programme.International journal of environmental research and public health · 2022Article
- Sex Moderates the Relationship Between Nausea Severity and Heart Rate Variability in Adolescents and Young Adults.Digestive diseases and sciences · 2022Article
- Initial exploration of the discriminatory ability of the PetPace collar to detect differences in activity and physiological variables between healthy and osteoarthritic dogs.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Objective pain stimulation intensity and pain sensation assessment using machine learning classification and regression based on electrodermal activity.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Interplay between social isolation and loneliness and chronic systemic inflammation during the COVID-19 pandemic in Japan: Results from U-CORONA study.Brain, behavior, and immunity · 2021Article
- A scoping review of chronic pain in emerging adults.Pain reports · 2021Article
- Heart Rate Variability and Gastric Electrical Response to a Cold Pressor Task in Youth with Functional Dyspepsia.Digestive diseases and sciences · 2020Article
- Sensor Technologies to Manage the Physiological Traits of Chronic Pain: A Review.Sensors (Basel, Switzerland) · 2020Review
- Commentary: Understanding Somatic Symptoms: From Dualism to Systems, Diagnosis to Dimensions, Clinical Judgement to Clinical Science.Journal of pediatric psychology · 2019Article
- Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population.BMC musculoskeletal disorders · 2019Article
- The Relationship Between Heart Rate Variability, Psychological Flexibility, and Pain in Neurofibromatosis Type 1.Pain practice : the official journal of World Institute of Pain · 2018Article
- Stress-induced hyperalgesia instead of analgesia in patients with chronic musculoskeletal pain.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Considerable research links chronic pain to autonomic nervous system (ANS) dysfunction, specifically low heart rate variability (HRV) mediated by reduced parasympathetic activity. However, little is known about factors that influence ANS function in chronic pain. The ANS is the primary pathway for brain-gut communication, making it of particular interest in gastrointestinal disorders, such as irritable bowel syndrome, characterized by functional abdominal pain (FAP). We evaluated the relation of sex, pain severity, and psychological stress to ANS function in adolescents/young adults from a database of pediatric FAP and control participants enrolled 8 years earlier in a prospective study of pain. At follow-up in adolescence/young adulthood (Mean age = 19.46, SD = 3.48), we classified participants as Pain-Remit (n = 130), Pain-Persist (n = 96), and pain-free controls (n = 123). We recorded electrocardiogram data at rest and during laboratory stressors. Results demonstrated significantly lower HRV in Pain-Persist females compared with Pain-Remit females, female controls, and all males regardless of pain category. Spectral analysis of electrocardiogram showed that Pain-Persist females had reduced power in the high frequency domain of cardiac activity, ie, reduced parasympathetic "braking" of sympathetic activity, both at rest and during stress. Pain-Remit females exhibited levels of autonomic imbalance intermediate between those of females with persistent FAP and all other participants. Parasympathetically mediated low HRV in young women with persistent FAP may reflect a peripheral mechanism (eg, gut dysfunction) or a central nervous system mechanism (eg, pain amplification or poor emotion self-regulation) involving prolonged sympathetic activation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.