ArticleJournal of the International AIDS Society2017
Loss to follow-up among children and adolescents growing up with HIV infection: age really matters.
Article in Journal of the International AIDS Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Behavioral Theories and Motivational Features Underlying eHealth Interventions for Adolescent Antiretroviral Adherence: Systematic Review.JMIR mHealth and uHealth · 2021Pooled it
- HIV Care Cascade Among Adolescents in a "Test and Treat" Community-Based Intervention: HPTN 071 (PopART) for Youth Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2021Trial
- Determinants of retention into HIV care among adolescents living with HIV in two selected districts in Copperbelt Province of Zambia.Journal of public health research · 2026Article
- Challenges with drug management of children and adolescents living with human immunodeficiency virus on antiretroviral therapy: A narrative review.African journal of primary health care & family medicine · 2026Review
- Incidence and predictors of loss to follow-up among youth living with HIV transitioning to adult care in Gambella, Southwest Ethiopia.BMC infectious diseases · 2026Article
- Challenges and Enablers of Antiretroviral Therapy Adherence Among Ethiopian Adolescents: A Qualitative Study.International journal of sexual health : official journal of the World Association for Sexual Health · 2026Article
- Retrospective cohort study of predictors of loss to follow up among adolescents and young adults living with HIV on ART in Dar es Salaam, Tanzania, 2015-2019.BMC infectious diseases · 2025Article
- Time-dependent predictors of loss to follow-up in HIV care in low-resource settings: A competing risks approach.PloS one · 2025Article
- Factors Associated with Loss to Follow-Up in Pediatric Concussion Patients after Initial Visit: A Retrospective Study at a Concussion Clinic.Journal of pediatrics. Clinical practice · 2024Article
- High mortality in adolescents and young adults with perinatally-acquired HIV in Thailand during the transition to adulthood.AIDS care · 2024Article
- Re-engagement and retention in HIV care after preventive default tracking in a cohort of HIV-infected patients in rural Malawi: A mixed-methods study.PLOS global public health · 2024Article
- Facilitated WhatsApp Support Groups for Youth Living With HIV in Nairobi, Kenya: Single-Arm Pilot Intervention Study.JMIR formative research · 2023Article
- 'They should show them love even if their status of being HIV positive is known': Youth and caregiver stigma experience and strategies to end HIV stigma in schools.Tropical medicine & international health : TM & IH · 2023Article
- Risk factors for interruption in treatment among HIV-infected adolescence attending health care and treatment clinics in Tanzania.AIDS research and therapy · 2023Article
- KNOWLEDGE, STIGMA, AND HIV TESTING: AN ANALYSIS OF A WIDESPREAD HIV/AIDS PROGRAM.Journal of development economics · 2023Article
- Mode of HIV acquisition among adolescents living with HIV in resource-limited settings: A data-driven approach from South Africa.PloS one · 2023Article
- Process evaluation of an intervention to improve HIV treatment outcomes among children and adolescents.Public health action · 2022Article
- Adherence challenges and opportunities for optimizing care through enhanced adherence counseling for adolescents with suspected HIV treatment failure in Kenya.BMC health services research · 2022Article
- Hope is No Plan: Uncovering Actively Missing Transition-Aged Youth with Congenital Heart Disease.Pediatric cardiology · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
introductionGlobally, increasing numbers of HIV-infected children are reaching adolescence due to antiretroviral therapy (ART). We investigated rates of loss-to-follow-up (LTFU) from HIV care services among children as they transition from childhood through adolescence.
methodsIndividuals aged 5-19 years initiated on ART in a public-sector HIV clinic in Bulawayo, Zimbabwe, between 2005 and 2009 were included in a retrospective cohort study. Participants were categorized into narrow age-bands namely: 5-9 (children), 10-14 (young adolescents) and 15-19 (older adolescents). The effect of age at ART initiation, current age (using a time-updated Lexis expansion) and transitioning from one age group to the next on LTFU was estimated using Poisson regression.
resultsOf 2273 participants, 1013, 875 and 385 initiated ART aged 5-9, 10-14 and 15-19 years, respectively. Unlike those starting ART as children, individuals starting ART as young adolescents had higher LTFU rates after moving to the older adolescent age-band (Adjusted rate ratio (ARR) 1.54; 95% CI: 0.94-2.55) and similarly, older adolescents had higher LTFU rates after transitioning to being young adults (ARR 1.79; 95% CI: 1.05-3.07). In older adolescents, the LTFU rate among those who started ART in that age-band was higher compared to the rate among those starting ART at a younger age (ARR = 1.70; 95% CI: 1.05, 2.77). This however did not hold true for other age-groups.
conclusionsAdolescents had higher rates of LTFU compared to other age-groups, with older adolescents at particularly high risk in all analyses. Age-updated analyses that examine movement across narrow age-bands are paramount in understanding how developmental heterogeneity in children affects HIV outcomes.
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