Evidence map›Paper›PMID 28715110›Full record

ArticleChembiochem : a European journal of chemical biology2017

Irreversible Protein Labeling by Paal-Knorr Conjugation.

Ramesh Dasari, James J La Clair, Alexander Kornienko

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In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ramesh DasariDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA.
James J La ClairDepartment of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA, 92093, USA.
Alexander KornienkoDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA.

Funding

Mode of Action of the Amaryllidaceae Alkaloid Lycorine-Promising Anticancer AgentR15CA186046 · NCI · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER · 2014 to 2014
$476k
NCI NIH HHS R15 CA186046
6 · The paper itself

Abstract

The application of new chemical reactions in a biological context has advanced bioconjugation methods for both fundamental research and commercial arenas. Recent adaptations of reactions such as Huisgen 1,3-dipolar or Diels-Alder cycloadditions have enabled the labeling of specific residues in biomolecules by the attachment of molecules carrying azides, alkynes, or strained alkenes. Although these are fundamental tools, there is a need for the discovery of reactions that can label native proteins. We report herein the adaptation of the Paal-Knorr reaction to label lysine residues in proteins via pyrrole linkages.

Indexed as

AlkynesAminesAnimalsAzidesCatalysisCattleClick ChemistryCycloaddition ReactionFluorescent DyesHCT116 CellsHumansMicroscopy, ConfocalPyrrolesSerum Albumin, BovineAlkynesAminesAzidesFluorescent DyesPyrrolesSerum Albumin, Bovinebiocompatible reactionsbioconjugationclick chemistryPaal-Knorr reactionprotein labeling

Identifiers

PMID28715110
PMCPMC5766258

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.