ArticleThe European journal of neuroscience2017
Drosophila mutants lacking octopamine exhibit impairment in aversive olfactory associative learning.
Article in The European journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Hunger recruits a parallel circuit encoding alcohol reward.Current biology : CB · 2026Article
- Selective octopaminergic tuning of mushroom body circuits during memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- ß-adrenergic-like signalling engages CrebB in Drosophila gut to promote female longevity.Nature communications · 2026Article
- Octopamine signaling from clock neurons plays dual roles in Drosophila long-term memory.PLoS genetics · 2026Article
- Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.PLoS biology · 2024Article
- Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila.Neuron · 2024Article
- Octopamine enhances learning.National science review · 2024Article
- Octopamine in the mushroom body circuitry for learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning.National science review · 2024Article
- An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning.bioRxiv : the preprint server for biology · 2024Article
- Dual roles of dopaminergic pathways in olfactory learning and memory in the oriental fruit fly, Bactrocera dorsalis.Pesticide biochemistry and physiology · 2024Article
- olf413 an octopamine biogenesis pathway gene is required for axon growth and pathfinding during embryonic nervous system development in Drosophila melanogaster.BMC research notes · 2024Article
- A PDMS-Agar Hybrid Microfluidic Device for the Investigation of Chemical-Mechanical Associative Learning Behavior ofMicromachines · 2023Article
- Article
- Regulation and modulation of biogenic amine neurotransmission inFrontiers in physiology · 2023Review
- Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain.eLife · 2021Article
- Variation in mobility and exercise adaptations between Drosophila species.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Concerted Actions of Octopamine and Dopamine Receptors Drive Olfactory Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- The Neurotransmitters Involved inFrontiers in behavioral neuroscience · 2020Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Octopamine is a biogenic amine in invertebrates that is considered a functional homolog of vertebrate norepinephrine, acting as a neurotransmitter, neuromodulator and neurohormone. Octopamine regulates many physiological processes such as metabolism, reproduction and different types of behaviour including learning and memory. Previous studies in insects led to the notion that acquisition of an olfactory memory depends on the octopaminergic system during appetitive (reward-based) learning, but not in the case of aversive (punishment-based) learning. Here, we provide several lines of evidence demonstrating that aversive associative olfactory learning in Drosophila is also dependent on octopamine signalling. Specifically, we used Drosophila Tβh (tyramine-β-hydroxylase) mutants, which lack octopamine and are female sterile, to determine whether octopamine plays a role in aversive learning. We show that Tβh mutant flies exhibit a significant reduction in learning compared to control lines that is independent of either genetic background or the methods used to induce aversive olfactory memory. We also show that the learning deficits observed in Tβh mutants are not due to defects in sensorimotor behaviours. Finally, to unambiguously demonstrate that octopamine synthesis plays a role in aversive olfactory learning, we performed rescue experiments using the Gal4/UAS system. We show that expression of UAS-Tβh in octopamine/tyraminergic neurons using Tdc2-Gal4 in Tβh null mutant flies fully rescued both the aversive learning defects and female sterility observed in Tβh mutants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.