Evidence map›Paper›PMID 28714976›Full record

ArticleNature genetics2017

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Rebecca Sims, Sven J van der Lee, Adam C Naj, Céline Bellenguez, Nandini Badarinarayan, Johanna Jakobsdottir, Brian W Kunkle, Anne Boland, Rachel Raybould, Joshua C Bis and 441 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 645 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
645citing papers in PubMed, 8 pooled it
57.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

645 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,083 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Review
  10. Article
  11. Review
  12. Aberrant phase separation from a rare ABI3 mutation drives microglial dysfunction and Alzheimer's risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  13. Review
  14. Article
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585 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

451 authors at 20 institutions in 20 countries.

Rebecca SimsInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Sven J van der LeeDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-1606-8643
Adam C NajDepartment of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9621-2942
Céline BellenguezINSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Nandini BadarinarayanInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID 0000-0002-6944-748X
Johanna JakobsdottirIcelandic Heart Association, Kopavogur, Iceland.
Brian W KunkleJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Anne BolandCEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
Rachel RaybouldInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Eden R MartinJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Benjamin Grenier-BoleyINSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Stefanie Heilmann-HeimbachInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Vincent ChourakiBoston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-4698-1794
Amanda B KuzmaPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Kristel SleegersNeurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.
Maria VronskayaInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Agustin RuizResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
Robert R GrahamImmunology Biomarkers Group, Genentech, South San Francisco, California, USA.ORCID 0000-0001-7151-4277
Robert OlasoCEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
Per HoffmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.ORCID 0000-0002-6573-983X
Megan L GroveSchool of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Badri N VardarajanTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Charles C WhiteProgram in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Kara L Hamilton-NelsonJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Jacques EpelbaumUMR 894, Center for Psychiatry and Neuroscience, INSERM, Université Paris Descartes, Paris, France.
Wolfgang MaierGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Seung-Hoan ChoiBoston University School of Medicine, Boston, Massachusetts, USA.
Gary W BeechamJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Cécile DularyCEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
Stefan HermsInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.ORCID 0000-0003-1942-5845
Cory C FunkInstitute for Systems Biology, Seattle, Washington, USA.
Céline DerboisCEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Shahzad AhmadDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Hongdong LiInstitute for Systems Biology, Seattle, Washington, USA.
Delphine BacqCEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
Denise HaroldSchool of Biotechnology, Dublin City University, Dublin, Ireland.
Claudia L SatizabalBoston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-1115-4430
Otto ValladaresPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Alessio SquassinaSection of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Rhodri ThomasInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-8509-148X
Liming QuPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Pascual Sánchez-JuanNeurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
Taniesha MorganInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Frank J WoltersDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-2226-4050
Yi ZhaoPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Florentino Sanchez GarciaDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Nicola DenningInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.
John MalamonPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Maria Candida Deniz NaranjoDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Elisa MajounieInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Thomas H MosleyDepartments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Beth DombroskiPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
David WallonCentre Hospitalier du Rouvray, Sotteville les Rouen, France.
Michelle K LuptonDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-7274-7299
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
Patrice WhiteheadJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Laura FratiglioniDepartment of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Christopher MedwayInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Xueqiu JianBrown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Lina KellerAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Kristelle BrownInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Honghuang LinSection of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0003-3043-3942
Laura B CantwellPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Francesco PanzaNeurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Bernadette McGuinnessCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
Sonia Moreno-GrauResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
Jeremy D BurgessDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Vincenzo SolfrizziGeriatric Medicine-Memory Unit and Rare Disease Centre, University of Bari Aldo Moro, Bari, Italy.
Petra ProitsiDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Hieab H AdamsDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-3687-2508
Mariet AllenDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Davide SeripaGeriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Pau PastorSection of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
L Adrienne CupplesFramingham Heart Study, Framingham, Massachusetts, USA.
Nathan D PriceInstitute for Systems Biology, Seattle, Washington, USA.
Didier HannequinINSERM U1079, Rouen University, IRIB, Normandy University, Rouen, France.
Ana Frank-GarcíaDepartment of Neurology, University Hospital La Paz, Universidad Autónoma de Madrid, Madrid, Spain.
Daniel LevyBoston University School of Medicine, Boston, Massachusetts, USA.
Paramita ChakrabartyCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.
Paolo CaffarraDepartment of Neuroscience, University of Parma, Parma, Italy.
Ina GieglingDepartment of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Alexa S BeiserFramingham Heart Study, Framingham, Massachusetts, USA.
Vilmantas GiedraitisDepartment of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-3423-2021
Harald HampelAXA Research Fund and UPMC Chair, Paris, France.
Melissa E GarciaLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
Xue WangDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Lars LannfeltDepartment of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
Patrizia MecocciSection of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur, Iceland.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Florence PasquierCentre Hospitalier Universitaire de Lille, Epidemiology and Public Health Department, Lille, France.ORCID 0000-0001-9880-9788
Virginia BoccardiSection of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Isabel HenándezResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
Robert C BarberDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Martin SchererDepartment of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Lluis TarragaResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
Perrie M AdamsDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Markus LeberDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
Yuning ChenDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-7358-7055
Marilyn S AlbertDepartment of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
Valur EmilssonIcelandic Heart Association, Kopavogur, Iceland.
Duane BeeklyNational Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
Anne BraaeSchools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.
Reinhold SchmidtDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.
Deborah BlackerDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Carlo MasulloDepartment of Neurology, Catholic University of Rome, Rome, Italy.
Helena SchmidtInstitute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria.
Rachelle S DoodyAlzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, Texas, USA.
Gianfranco SpallettaExperimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
W T LongstrethDepartment of Neurology, University of Washington, Seattle, Washington, USA.
Thomas J FairchildOffice of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Paola BossùExperimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.ORCID 0000-0002-1432-0078
Oscar L LopezDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Matthew P FroschC.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Eleonora SacchinelliExperimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.ORCID 0000-0002-1842-8019
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-3658-1375
Ryan M HuebingerDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Frank JessenGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Shuo LiDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.
M Ilyas KambohAlzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John MorrisDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Oscar Sotolongo-GrauResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
Mindy J KatzDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Chris CorcoranDepartment of Mathematics and Statistics, Utah State University, Logan, Utah, USA.
Melanie DunstanInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Amy BraddelInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Charlene ThomasInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Alun MeggyInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Rachel MarshallInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Amy GerrishInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Jade ChapmanInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Miquel AguilarFundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain.
Sarah TaylorInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Matt HillInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Mònica Díez FairénCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Angela HodgesDepartment of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Bruno VellasINSERM U558, University of Toulouse, Toulouse, France.
Hilkka SoininenDepartment of Neurology, Kuopio University Hospital, Kuopio, Finland.
Iwona KloszewskaElderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland.
Makrina DaniilidouDepartment of Health Sciences, Psychiatry for the Elderly, University of Leicester, Leicester, UK.
James UphillDepartment of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
Yogen PatelDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Joseph T HughesDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Jenny LordInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
James TurtonInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Annette M HartmannDepartment of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Roberta CecchettiSection of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.
Chiara FenoglioDepartment of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Maria SerpenteDepartment of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Marina ArcaroDepartment of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Carlo CaltagironeExperimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
Maria Donata OrfeiExperimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
Antonio CiaramellaExperimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy.
Sabrina PichlerDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Manuel MayhausDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Wei GuDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Alberto LleóCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Juan ForteaCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Rafael BlesaCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Imelda S BarberSchools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.
Keeley BrookesSchools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK.
Chiara CupidiRegional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
Raffaele Giovanni MalettaRegional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
David CarrellDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
Sandro SorbiNEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.
Susanne MoebusInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
Maria UrbanoGeriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Alberto PilottoGeriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Johannes KornhuberDepartment of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
Paolo BoscoIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy.
Stephen ToddCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
David CraigCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
Janet JohnstonCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
Michael GillMercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.
Brian LawlorMercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.
Aoibhinn LynchMercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland.
Nick C FoxDepartment of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
John HardyDepartment of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
ARUK Consortium
Roger L AlbinDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Liana G ApostolovaIndiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Steven E ArnoldDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Sanjay AsthanaGeriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.
Craig S AtwoodGeriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA.
Clinton T BaldwinDepartment of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA.
Lisa L BarnesDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
Sandra BarralTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
Thomas G BeachCivin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona, USA.
James T BeckerDepartments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Eileen H BigioDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Thomas D BirdDepartment of Neurology, University of Washington, Seattle, Washington, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
James D BowenSwedish Medical Center, Seattle, Washington, USA.
Adam BoxerDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
James R BurkeDepartment of Medicine, Duke University, Durham, North Carolina, USA.
Jeffrey M BurnsUniversity of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
Joseph D BuxbaumDepartment of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA.
Nigel J CairnsDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
Chuanhai CaoUSF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA.
Chris S CarlsonFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Cynthia M CarlssonDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Regina M CarneyDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Minerva M CarrasquilloDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Steven L CarrollDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Carolina Ceballos DiazCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.
Helena C ChuiDepartment of Neurology, University of Southern California, Los Angeles, California, USA.
David G ClarkDepartment of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
David H CribbsDepartment of Neurology, University of California, Irvine, Irvine, California, USA.
Elizabeth A CroccoDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Charles DeCarliDepartment of Neurology, University of California, Davis, Sacramento, California, USA.
Malcolm DickInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
Ranjan DuaraWien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida, USA.
Denis A EvansRush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Kelley M FaberDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.
Kenneth B FallonDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
David W FardoSanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, Kentucky, USA.
Martin R FarlowDepartment of Neurology, Indiana University, Indianapolis, Indiana, USA.
Steven FerrisDepartment of Psychiatry, New York University, New York, New York, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.
Douglas R GalaskoDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Marla GearingDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
Daniel H GeschwindNeurogenetics Program, University of California, Los Angeles, Los Angeles, California, USA.
John R GilbertJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Neill R Graff-RadfordDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Robert C GreenDivision of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
John H GrowdonDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Ronald L HamiltonDepartment of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lindy E HarrellDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Lawrence S HonigTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
Matthew J HuentelmanNeurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.
Christine M HuletteDepartment of Pathology, Duke University, Durham, North Carolina, USA.
Bradley T HymanDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Gail P JarvikDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
Erin AbnerSanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA.
Lee-Way JinDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA.
Gyungah JunDepartment of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA.
Anna KarydasDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Jeffrey A KayeDepartment of Neurology, Oregon Health &Science University, Portland, Oregon, USA.
Ronald KimDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA.
Neil W KowallDepartment of Neurology, Boston University, Boston, Massachusetts, USA.
Joel H KramerDepartment of Neuropsychology, University of California, San Francisco, San Francisco, California, USA.
Frank M LaFerlaDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA.
James J LahDepartment of Neurology, Emory University, Atlanta, Georgia, USA.
James B LeverenzCleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA.
Allan I LeveyDepartment of Neurology, Emory University, Atlanta, Georgia, USA.
Ge LiDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
Andrew P LiebermanDepartment of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Kathryn L LunettaDepartment of Biostatistics, Boston University, Boston, Massachusetts, USA.
Constantine G LyketsosDepartment of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA.
Daniel C MarsonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Frank MartiniukDepartment of Medicine-Pulmonary, New York University, New York, New York, USA.
Deborah C MashDepartment of Neurology, University of Miami, Miami, Florida, USA.
Eliezer MasliahDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA.
Wayne C McCormickDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Susan M McCurrySchool of Nursing Northwest Research Group on Aging, University of Washington, Seattle, Washington, USA.
Andrew N McDavidFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Ann C McKeeDepartment of Neurology, Boston University, Boston, Massachusetts, USA.
Marsel MesulamCognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Bruce L MillerDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Carol A MillerDepartment of Pathology, University of Southern California, Los Angeles, California, USA.
Joshua W MillerDepartment of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA.
John C MorrisDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
Jill R MurrellDepartment of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
Amanda J MyersDepartment of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Sid O'BryantInternal Medicine, Division of Geriatrics, University of North Texas Health Science Center, Fort Worth, Texas, USA.
John M OlichneyDepartment of Neurology, University of California, Davis, Sacramento, California, USA.
Vernon S PankratzDepartment of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Joseph E ParisiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Henry L PaulsonDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
William PerryJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Elaine PeskindDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
Aimee PierceDepartment of Neurology, University of California, Irvine, Irvine, California, USA.
Wayne W PoonInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA.
Huntington PotterDepartment of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Joseph F QuinnDepartment of Neurology, Oregon Health &Science University, Portland, Oregon, USA.
Ashok RajUSF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA.
Murray RaskindDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
Barry ReisbergDepartment of Psychiatry, New York University, New York, New York, USA.
Christiane ReitzGertrude H. Sergievsky Center, Columbia University, New York, New York, USA.
John M RingmanDepartment of Neurology, University of California, Los Angeles, Los Angeles, California, USA.
Erik D RobersonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ekaterina RogaevaTanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
Howard J RosenDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Roger N RosenbergDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Mark A SagerDepartment of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Andrew J SaykinDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA.
Julie A SchneiderDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
Lon S SchneiderDepartment of Neurology, University of Southern California, Los Angeles, California, USA.
William W SeeleyDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Amanda G SmithUSF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA.
Joshua A SonnenDepartment of Pathology, University of Washington, Seattle, Washington, USA.
Salvatore SpinaDepartment of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA.
Robert A SternDepartment of Neurology, Boston University, Boston, Massachusetts, USA.
Russell H SwerdlowUniversity of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA.
Rudolph E TanziDepartment of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Tricia A Thornton-WellsTranslational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
John Q TrojanowskiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Juan C TroncosoDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Vivianna M Van DeerlinDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Linda J Van EldikSanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA.
Harry V VintersDepartment of Neurology, University of California, Los Angeles, Los Angeles, California, USA.
Jean Paul VonsattelTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York, USA.
Sandra WeintraubCognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kathleen A Welsh-BohmerDepartment of Medicine, Duke University, Durham, North Carolina, USA.
Kirk C WilhelmsenDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jennifer WilliamsonTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
Thomas S WingoDepartment of Neurology, Emory University, Atlanta, Georgia, USA.
Randall L WoltjerDepartment of Pathology, Oregon Health &Science University, Portland, Oregon, USA.
Clinton B WrightEvelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Chang-En YuDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Lei YuDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
Fabienne GarziaCEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
Feroze GolamaullyCEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
Gislain SeptierCEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
Sebastien EngelborghsInstitute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Rik VandenbergheDepartment of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium.
Peter P De DeynInstitute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Carmen Muñoz FernadezDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Yoland Aladro BenitoDepartment of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain.
Hakan ThonbergDepartment of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Charlotte ForsellDepartment of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Lena LiliusDepartment of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Anne Kinhult-StählbomDepartment of Geriatric Medicine, Genetics Unit, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Lena KilanderDepartment of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
RoseMarie BrundinDepartment of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
Letizia ConcariDepartment of Neuroscience, University of Parma, Parma, Italy.
Seppo HelisalmiDepartment of Neurology, Kuopio University Hospital, Kuopio, Finland.
Anne Maria KoivistoDepartment of Neurology, Kuopio University Hospital, Kuopio, Finland.
Annakaisa HaapasaloDepartment of Neurology, Kuopio University Hospital, Kuopio, Finland.
Vincent DermecourtCHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France.
Nathalie FievetINSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.
Olivier HanonUniversity Paris Descartes, EA 4468, AP-HP, Hôpital Broca, Geriatrics Department, Paris, France.
Carole DufouilUniversity of Bordeaux, Neuroepidemiology, Bordeaux, France.
Alexis BriceINSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Karen RitchieINSERM U1061, La Colombière Hospital, Montpellier, France.
Bruno DuboisInstitut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
Jayanadra J HimaliBoston University School of Medicine, Boston, Massachusetts, USA.
C Dirk KeeneDepartment of Pathology, University of Washington, Seattle, Washington, USA.
JoAnn TschanzDepartment of Mathematics and Statistics, Utah State University, Logan, Utah, USA.
Annette L FitzpatrickDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Walter A KukullDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Maria NortonDepartment of Mathematics and Statistics, Utah State University, Logan, Utah, USA.
Thor AspelundIcelandic Heart Association, Kopavogur, Iceland.ORCID 0000-0002-7998-5433
Eric B LarsonDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Ron MungerDepartment of Mathematics and Statistics, Utah State University, Logan, Utah, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Richard B LiptonDepartment of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
María J BullidoInstituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain.ORCID 0000-0002-6477-1117
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Thomas J MontineDepartment of Pathology, University of Washington, Seattle, Washington, USA.
Eliecer CotoMolecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
Eric BoerwinkleSchool of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Victoria AlvarezMolecular Genetics Laboratory-Hospital, University of Central Asturias, Oviedo, Spain.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID 0000-0001-9435-9441
Eric M ReimanNeurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA.
Maura GalloRegional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
Christopher J O'DonnellFramingham Heart Study, Framingham, Massachusetts, USA.
Joan S ReischDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Amalia Cecilia BruniRegional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy.
Donald R RoyallDepartments of Psychiatry, Medicine, and Family and Community Medicine and South Texas Veterans Health Administration Geriatric Research Education and Clinical Center (GRECC), University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Martin DichgansInstitute for Stroke and Dementia Research, Klinikum der Universität München, Munich, Germany.
Mary SanoDepartment of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA.
Daniela GalimbertiDepartment of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Peter St George-HyslopTanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada.
Elio ScarpiniDepartment of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Debby W TsuangDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
Michelangelo MancusoDepartment of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
Ubaldo BonuccelliDepartment of Experimental and Clinical Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
Ashley R WinslowPharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, USA.
Antonio DanieleInstitute of Neurology, Catholic University of Sacred Hearth, Rome, Italy.
Chuang-Kuo WuDepartments of Neurology, Pharmacology, and Neuroscience, Texas Tech University Health Science Center, Lubbock, Texas, USA.
GERAD/PERADES, CHARGE, ADGC, EADI
Oliver PetersDepartment of Psychiatry, Charité University Medicine, Berlin, Germany.
Benedetta NacmiasNEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy.
Matthias RiemenschneiderDepartment of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany.
Reinhard HeunDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Carol BrayneInstitute of Public Health, University of Cambridge, Cambridge, UK.
David C RubinszteinCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5002-5263
Jose BrasDepartment of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
Rita GuerreiroDepartment of Molecular Neuroscience, UCL, Institute of Neurology, London, UK.
Ammar Al-ChalabiInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-4924-7712
Christopher E ShawInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
John CollingeDepartment of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
David MannInstitute of Brain, Behaviour and Mental Health, Clinical and Cognitive Neuroscience Research Group, University of Manchester, Manchester, UK.
Magda Tsolaki3rd Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0002-2072-8010
Jordi ClarimónCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Rebecca SussamsDivision of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK.
Simon LovestoneDepartment of Psychiatry, University of Oxford, Oxford, UK.
Michael C O'DonovanInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Michael J OwenInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Timothy W BehrensImmunology Biomarkers Group, Genentech, South San Francisco, California, USA.
Simon MeadDepartment of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.
Alison M GoateDepartment of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA.
Andre G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Clive HolmesVA Puget Sound Health Care System/GRECC, Seattle, Washington, USA.
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Martin IngelssonDepartment of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden.
David A BennettDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
John PowellDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Todd E GoldeCenter for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA.
Caroline GraffDepartment of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Philip L De JagerCenter for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0002-8057-2505
Kevin MorganInstitute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Nilufer Ertekin-TanerDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Onofre CombarrosNeurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Peter PassmoreCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.
Steven G YounkinDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Claudine BerrInstitut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Dan RujescuDepartment of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0001-7189-7917
Jean-François DartiguesMemory Research and Resources Center, CMRR de Bordeaux, Bordeaux, France.
Anita L DeStefanoFramingham Heart Study, Framingham, Massachusetts, USA.
Sara Ortega-CuberoCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Hakon HakonarsonCenter for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Dominique CampionCentre Hospitalier du Rouvray, Sotteville les Rouen, France.
Merce BoadaResearch Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain.
John Keoni KauweDepartments of Biology and Neuroscience, Brigham Young University, Provo, Utah, USA.
Lindsay A FarrerBoston University School of Medicine, Boston, Massachusetts, USA.
Christine Van BroeckhovenNeurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.ORCID 0000-0003-0183-7665
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID 0000-0003-0372-8585
Lesley JonesInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Jonathan L HainesDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
Christophe TzourioINSERM U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
Valentina Escott-PriceInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Richard MayeuxTaub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
Jean-François DeleuzeCEA/Institut de Génomique, Centre National de Génotypage, Evry, France.
Najaf AminDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Peter A HolmansInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA.
Philippe AmouyelINSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.ORCID 0000-0001-9088-234X
Cornelia M van DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Alfredo RamirezInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Li-San WangPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Jean-Charles LambertINSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France.ORCID 0000-0003-0829-7817
Sudha SeshadriBoston University School of Medicine, Boston, Massachusetts, USA.
Julie WilliamsInstitute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Gerard D SchellenbergPenn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Boston University · USUniversity of Miami · USUniversity of Washington · USInserm · FRUniversity of Bonn · DECardiff University · GBUniversity of Nottingham · GBCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRKing's College London · GBErasmus MC · NLKarolinska University Hospital · SEQueen's University Belfast · GBUniversity of Milan · ITUppsala University · SEUtah State University · USRush University Medical Center · USUniversity of Antwerp · BEEmory University · USHarvard University · USJacksonville College · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
TRIAL OF VALPROATE TO ATTENUATE THE PROGRESSION OF ADU01AG010483 · NIA · UNIVERSITY OF ROCHESTER · PI AISEN, PAUL S. · 1991 to 2012
$116.2M
Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI Charles B Hall · 1985 to 2026
$73.9M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
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6 · The paper itself

Abstract

We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10

Indexed as

Polymorphism, Single NucleotideAdaptor Proteins, Signal TransducingAlzheimer DiseaseAmino Acid SequenceCase-Control StudiesExomeGene Expression ProfilingGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansImmunity, InnateLinkage DisequilibriumMembrane GlycoproteinsMicrogliaOdds RatioABI3 protein, humanAdaptor Proteins, Signal TransducingMembrane GlycoproteinsPhospholipase C gammaReceptors, ImmunologicTREM2 protein, human

Identifiers

PMID28714976
PMCPMC5669039
OpenAlexW2592518050

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