Evidence map›Paper›PMID 28714850›Full record

ArticleeLife2017

High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast.

Yi Yin, Margaret Dominska, Eunice Yim, Thomas D Petes

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

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  11. Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Article
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  16. POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Article
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  19. Article
  20. Multi-Invasion-Induced Rearrangements as a Pathway for Physiological and Pathological Recombination.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yi YinDepartment of Molecular Genetics and Microbiology and University Program in Genetics and Genomics, Duke University Medical Center, Durham, United States.ORCID 0000-0003-0963-2672
Margaret DominskaDepartment of Molecular Genetics and Microbiology and University Program in Genetics and Genomics, Duke University Medical Center, Durham, United States.
Eunice YimDepartment of Molecular Genetics and Microbiology and University Program in Genetics and Genomics, Duke University Medical Center, Durham, United States.
Thomas D PetesDepartment of Molecular Genetics and Microbiology and University Program in Genetics and Genomics, Duke University Medical Center, Durham, United States.ORCID 0000-0003-4890-8002
Duke University · US

Funding

Genetics Training Grant-Year 26T32GM007754 · NIGMS · DUKE UNIVERSITY · PI HAASE, STEVEN B · 1985 to 2019
$8.3M
Genetic regulation of genome stability in yeastR35GM118020 · NIGMS · DUKE UNIVERSITY · PI PETES, THOMAS · 2016 to 2025
$7.0M
RECOMBINATION IN YEASTR01GM024110 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI PETES, THOMAS · 1985 to 2015
$6.1M
INSTABILITY OF SIMPLE REPETITIVE DNA SEQUENCES IN YEASTR01GM052319 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI PETES, THOMAS · 1995 to 2015
$4.9M
NIGMS NIH HHS R01 GM024110NIGMS NIH HHS R01 GM052319NIGMS NIH HHS R35 GM118020NIGMS NIH HHS T32 GM007754
6 · The paper itself

Abstract

In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule. If the two strands of DNA are not identical, there will be mismatches within the heteroduplex DNA (hetDNA). In wild-type strains, these mismatches are repaired by the mismatch repair (MMR) system, producing a gene conversion event. In strains lacking MMR, the mismatches persist. Most previous studies involving hetDNA formed during mitotic recombination were restricted to one locus. Below, we present a global mapping of hetDNA formed in the MMR-defective

Indexed as

Recombination, GeneticUltraviolet RaysBrain NeoplasmsColorectal NeoplasmsDNA, FungalMitosisMutL Protein Homolog 1Neoplastic Syndromes, HereditaryNucleic Acid HeteroduplexesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA, FungalMLH1 protein, S cerevisiaeMutL Protein Homolog 1Nucleic Acid HeteroduplexesSaccharomyces cerevisiae Proteinschromosomesgene conversiongenesgenome rearrangementsgenome-wide mappingheteroduplex DNAmismatch repairmitotic recombinationS. cerevisiae

Identifiers

PMID28714850
PMCPMC5531827
OpenAlexW2950182280

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.